Tumor Immunoediting, from T Cell-Mediated Immune Surveillance to Tumor-Escape of Uterine Leiomyosarcoma
Takuma Hayashi1,10*, Akiko Horiuchi2,11, Kenji Sano3, Nobuyoshi Hiraoka4, Tomoyuki Ichimura5, Osamu Ishiko5, Yae Kanai4, Nobuo Yaegashi6, Hiroyuki Aburatani7, Tanri Shiozawa2, Susumu Tonegawa8 and Ikuo Konishi9
- *Corresponding Author:
- Dr. Takuma Hayashi
Department of Immunology and Infectious Disease
Shinshu University Graduate School of Medicine, 3-1-1, Asahi
Matsumoto, Nagano 390-8621, Japan
E-mail: [email protected]
Received date: October 21, 2011; Accepted date: February 24, 2012; Published date: February 28, 2012
Citation: Hayashi T, Horiuchi A, Sano K, Hiraoka N, Ichimura T, et al.(2012) Tumor Immunoediting, from T Cell-Mediated Immune Surveillance to Tumor-Escape of Uterine Leiomyosarcoma. J Vaccines Vaccin S1:002. doi: 10.4172/2157-7560.S1-002
Copyright: © 2012 Hayashi T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The majority of smooth muscle tumors found in the uterus are benign, but uterine leiomyosarcomas (LMSs) are extremely malignant, with high rates of recurrence and metastasis. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not clearly understood. The presentation of antigenic peptides by major histocompatibility complex (MHC) class I molecules is important for tumor rejection by cytotoxic T-lymphocytes (CTLs). Such antigenic peptides are generated as a result of the degradation of intracellular proteins by the proteasome pathway, a process that is influenced by the interferon (IFN)-γ-inducible low molecular mass polypeptide-2 (LMP2) subunit of the 20S proteasome. Homozygous deficient mice for LMP2 are now known to spontaneously develop uterine LMS. LMP2 expression is reportedly absent in human uterine LMS, but present in human myometrium. Further studies revealed a few infiltrating CD56+ NK cells in human uterine LMS tissues. This review aims at summarizing recent insights into the regulation of NK cell function and the T cell-mediated immune system as tumor immune surveillance, first attempts to exploit NK cell activation to improve immunity to tumors.