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Two-hit Reprograming of Induced Pluripotent Stem Cells
Kazunari K Yokoyama*Graduate Institute of Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, San-Ming District, 807 Kaohsiung, Taiwan
- *Corresponding Author:
- Kazunari K Yokoyama
Graduate Institute of Medicine
Kaohsiung Medical University, 100 Shih-Chuan 1st Road
San-Ming District, 807 Kaohsiung, Taiwan
Tel: +886-7-312-1101
Fax: +886-7-313-3849
E-mail: kazu@kmu.edu.tw
Received date: May 09, 2014; Accepted date: June 24, 2014; Published date: June 27, 2014
Citation: Yokoyama KK (2014) Two-hit Reprograming of Induced Pluripotent Stem Cells. Occup Med Health Aff 2:168. doi: 10.4172/2329-6879.1000168
Copyright: © 2014 Yokoyama KK. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Endogenous and exogenous stresses produce reactive oxygen species (ROS) in cells, and these can cause DNA damage, apoptosis, autophagy, and senescence. The reprogramming of somatic cells to produce induced pluripotent stem cells (iPSCs) initially requires ROS production and then represses the endogenous expression of tumor suppressor factors such as p53, p21Cip1, and p16Ink4a. This article discusses a two-hit model of stress-induced reprogramming for generating iPSCs and suggests new clinical tools for stem cell therapy.
