alexa Type 1 IFN-alpha Receptor Expression in Peripheral Blood Lymphocytes Independently Predicts Sustained Virological Response in Chronic Hepatitis C Genotype 1b with High Viral Load
ISSN: 2165-7831

Journal of Blood & Lymph
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Type 1 IFN-alpha Receptor Expression in Peripheral Blood Lymphocytes Independently Predicts Sustained Virological Response in Chronic Hepatitis C Genotype 1b with High Viral Load

Kaori Kanayama, Koji Ishii*, Mie Shinohara, Michio Kogame, and Yasukiyo Sumino

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University School of Medicine, Toho University, 6-11-1, Omorinishi, Otaku, Tokyo 143-8541, Japan

*Corresponding Author:
Koji Ishii
Division of Gastroenterology and Hepatology
Department of Internal Medicine
Toho University School of Medicine
Toho University, 6-11-1 Omorinishi, Ota-ku,
Tokyo 143-8541, Japan
Tel: +81-3-3762-4151
Fax: +81-3-3763-8542
E-mail: [email protected]

Received Date: September 28, 2012; Accepted Date: October 30, 2012; Published Date: November 01, 2012

Citation: Koji I, Kaori K, Mie S, Michio K, Masao S, et al. (2012) Type 1 IFN-alpha Receptor Expression in Peripheral Blood Lymphocytes Independently Predicts Sustained Virological Response in Chronic Hepatitis C Genotype 1b with High Viral Load. J Blood Lymph 2:109. doi:10.4172/2165-7831.1000109

Copyright: © 2012 Koji I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

 Background: We have been investigating serial changes in Type I Interferon (IFN) receptor alpha-2 (IFNAR-2)

expression in peripheral blood leukocyte subsets in Chronic Hepatitis C (CHC) patients during IFN-based therapy.
The aim of this study was to clarify whether changes in IFNAR-2 expression by peripheral blood leukocyte subsets
are predictive factors for Sustained Virological Response (SVR).
Methods: One hundred and thirty-six patients with CHC and receiving Pegylated (PEG)-IFN alpha-2a or -2b in
combination with ribavirin (RBV) for a median 48 (16-96) weeks were studied. A negative result for serum HCV-RNA
on RT-PCR at week 24 after the End Of Therapy (EOT) was defined as SVR. IFNAR-2 expression by peripheral
blood leukocyte subsets was quantified using flow cytometry by measuring the mean fluorescence intensity before
and up to 28 days after therapy initiation. Of the 136 patients, 124 consented to genetic investigation for interleukin
(IL)-28B genetic variants at rs8099917. We then used logistic regression analysis to retrospectively investigate the
influence of serum viral load, as measured before the start of therapy, and age, sex, body weight, body mass index,
IFN regimen, IFN dose/kg, RBV dose/kg and history of prior IFN-based therapy on SVR.
Results: Overall SVR rate was 53% (77/146). Of the 97 patients with IL-28 genotype TT, 67 (69%) showed
SVR. In contrast, of the 27 patients with IL-28 genotype TG, 5 (19%) showed SVR. IL-28B genotype at rs8099917
and patient age were factors having an independent influence on SVR on multivariate regression analysis. When we
added serial changes in IFNAR-2 expression by leukocyte subsets before and up to 28 days after EOT to the logistic
regression model, IFNAR-2 expression by lymphocytes at day 28 was identified as an independent additive factor.
Conclusion: This study provided the first evidence that IFNAR-2 expression by peripheral blood lymphocytes
is an additive but independent factor predicting SVR to PEG-IFN and RBV in patients with CHC genotype 1b and
high viral load.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords