alexa Type 2 Diabetes Mellitus is an Independent Risk Factor for Postoperative Complications in Patients Surgically Treated for Meningioma | OMICS International | Abstract
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
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Research Article

Type 2 Diabetes Mellitus is an Independent Risk Factor for Postoperative Complications in Patients Surgically Treated for Meningioma

Arash Nayeri1*, Silky Chotai2, Diana G Douleh3, Philip R Brinson2, Marc A Prablek3, Kyle D Weaver2, Reid C Thompson2 and Lola Chambless2

1Vanderbilt University Medical Center, 1161 21st Ave S, Rm T-4224 MCN, Nashville, TN 37232-2380, USA

2Department of Neurosurgery, Vanderbilt University Medical Center, 1161 21st Ave S, Rm T-4224 MCN, Nashville, TN 37232-2380, USA

3Vanderbilt University School of Medicine, 201 Light Hall, Nashville, TN 37232, USA

*Corresponding Author:
Vanderbilt University Medical Center
1161 21st Ave S, Rm T-4224 MCN
Nashville, TN 37232-2380, USA
Tel: 310-383-5085;
Email: [email protected]

Received date: March 22, 2016; Accepted date: April 20, 2016; Published date: April 27, 2016

Citation: Nayeri A, Chotai S, Douleh DG, Brinson PR, Prablek MA, et al. (2016) Type 2 Diabetes Mellitus is an Independent Risk Factor for Postoperative Complications in Patients Surgically Treated for Meningioma. J Neurol Neurophysiol 7: 368. doi: 10.4172/2155-9562.1000368

Copyright: © 2016 Nayeri A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objectives: Increased risk of perioperative complications in patients with type 2 diabetes mellitus (DM) has previously been noted with regard to a number of different operations. We sought to study the relative rates of postoperative complications after the surgical resection of an intracranial meningioma based on a pre-existing diagnosis of diabetes.
Methods: We conducted a retrospective cohort study on 259 patients who underwent a primary meningioma resection at our institution between 2001-2013. The medical record was reviewed to identify a pre-existing diagnosis of type 2 DM and any postoperative complications prior to discharge. The duration of postoperative hospital stay, intensive care unit (ICU) stay, perioperative changes in Karnofsky Performance Status (KPS) scores, and any postoperative emergency department (ED) presentation within 90 days of the operation were also recorded for each patient. Multivariable logistic regression models were built to determine the impact of a history of diabetes on postoperative complications and post-discharge presentation to the ED. Multivariable linear regression models were designed to assess the predictors of lengthier hospitalization and ICU stays in addition to differential postoperative changes in KPS scores.
Results: Forty-one (16%) patients had diagnoses of type 2 DM prior to clinical presentation. In multivariate analyses, patients with a pre-existing history of diabetes had a higher risk of postoperative complications, postoperative ED presentation, and deterioration in functional status in addition to lengthier durations of hospitalization and ICU stay (p<0.001, p=0.008, p<0.001, p=0.007, p<0.001).
Conclusions:
Patients with pre-existing diagnoses of type 2 DM have a significantly increased risk of immediate postoperative complications following the resection of an intracranial meningioma. Type 2 DM also predicts increased lengths of postoperative hospital stay, decreased postoperative performance status, and increased risk of postoperative ED presentation.

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