alexa Type 3 Diabetes Reflects Disordered Lipid Metabolism in
ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
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Research Article

Type 3 Diabetes Reflects Disordered Lipid Metabolism in the Human Brain Related to Higher Degree of Unsaturated Fatty Acids Composition and is not Related to Body Mass Index

Vincent van Ginneken1*, Evert de Vries1, Verheij E2 and Jan van der Greef2,3

1Blue Green Technologies, Runderweg 6, 8219 PK Lelystad, The Netherlands

2Netherlands Organisation for Applied Scientific Research (TNO), Utrechtseweg, AJ Zeist, The Netherlands

3Sino-Dutch Center for Preventive and Personalized Medicine, Leiden University, RA Leiden, The Netherlands

*Corresponding Author:
Vincent van Ginneken
Blue Green Technologies, Runderweg 6
8219 PK Lelystad, The Netherlands
Tel: 310638071180
E-mail: [email protected]

Received date: June 03, 2017; Accepted date: June 20, 2017; Published date: June 27, 2017

Citation: Ginneken VV, Vries Ede, Verheij E, Greef JVD (2017) Type 3 Diabetes Reflects Disordered Lipid Metabolism in the Human Brain Related to Higher Degree of Unsaturated Fatty Acids Composition and is not Related to Body Mass Index. J Bioanal Biomed 9:159-163. doi: 10.4172/1948-593X.1000171

Copyright: © 2017 Ginneken VV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

In this study we investigated lipid profiles of brain of post mortem type 2 diabetes patients T2DM elderly patients in comparison to a Control group (Co) of the “Netherlands Brain Bank” using LCMS techniques. Here we report that brains of these T2DM patients contain more double bonds and consequently are more rigid. In a small cohort (≈200 patients) we prove that these brain diseases are not interrelated with BMI so obesity is not a major cause. The predicted wave of brain diseases of mild-Alzheimer (m-AD), dementia and depression of the “baby boom generation” might be evolved due to the “fatty” and more “rigid” brain structure due to the quality of fats eaten during earlier lifespan. Our major conclusion is that diabetes and its treatment among T2DM patients are more associated with structural disturbances (lipid composition) in the brain than with glycaemic control. Therefore we introduce the new terminology “Type 3 diabetes” (T3DM) referring to the mental disorders as a consequence of a disordered lipid metabolism in the human brain related to higher degree of unsaturated fatty acids composition.

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