alexa Ultrasound-mediated Microbubble Destruction Promotes Bone Marrow Mesenchymal Stem Cell Transplantation for Myocardial Infarction Therapy
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
Open Access

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Research Article

Ultrasound-mediated Microbubble Destruction Promotes Bone Marrow Mesenchymal Stem Cell Transplantation for Myocardial Infarction Therapy

Fuchao Yu, Jinyu Li, Zhuo Xu, Zhouzhou Lu, Xiaohui Zhang, Dan Li and Jiayi Tong*
Institute of Cardiology, Southeast University, Nanjing, Jiangsu Province, China
Corresponding Author : Jiayi Tong
Institute of Cardiology
Southeast University, Nanjing 210009
Jiangsu Province, China
Tel: +86-25-83262415
E-mail: [email protected]
Received September 03, 2014; Accepted September 08, 2014; Published September 18, 2014
Citation: Yu F, Li J, Xu Z, Lu Z, Zhang X, et al. (2014) Ultrasound-mediated Microbubble Destruction Promotes Bone Marrow Mesenchymal Stem Cell Transplantation for Myocardial Infarction Therapy. J Clin Exp Cardiolog 5:333. doi:10.4172/2155-9880.1000333
Copyright: © 2014 Tong J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The study was designed to investigate whether ultrasound-mediated microbubble destruction can enhance the transplantation of bone marrow mesenchymal stem cells (BMSCs) for myocardial infarction therapy, twenty myocardial infarction pigs were assigned into the ultrasound microbubble destruction group (n=12, Sonovue were infused into coronary artery with ultrasonic radiation, then BMSCs were injected into infarction region) and the cell control group (n=8, only subjected to BMSCs treatment). The increase of left ventricular ejection fraction was larger in the ultrasound microbubble destruction group (P<0.01), and more Prussian blue-positive cells and higher density of heart muscle capillary in the peripheral infarct regions were found (P<0.01). Prussian blue-positive cells were differentiated into new vascular endothelial cells in two cases, among which the gaps were widened in the microbubble destruction group. Our study first time testifies in pig models that ultrasound-mediated microbubble destruction promotes BMSC transplantation for myocardial infarction therapy.

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