alexa Ultrastructural and Antioxidant Studies of Etoposide Treated Kidney of Rat
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Ultrastructural and Antioxidant Studies of Etoposide Treated Kidney of Rat

Pratibha Kamble1*, Sameer Kulkarni2and Dayanand A. Bhiwgade3

1Department of Life Sciences, University of Mumbai, Kalina, Santacruz (E) 400098, Mumbai, India

2Department of Biochemistry, Grant Medical College and Sir J.J.Group of Hospitals, Byculla, Mumbai, India

3Department of Biological Sciences, D.Y.Patil University, Belapur, Navi Mumbai, India

*Corresponding Author:
Pratibha R. Kamble
Department of Life Sciences
University of Mumbai, Kalina
Santacruz (E) 400098, Mumbai, India
Tel: 6143307068
E-mail: [email protected]

Received date: February 23, 2013; Accepted date: March 11, 2013; Published date: March 13, 2013

Citation: Kamble P, Kulkarni S, Bhiwgade DA (2013) Ultrastructural and Antioxidant Studies of Etoposide Treated Kidney of Rat. J Cancer Sci Ther 5:137-141. doi:10.4172/1948-5956.1000199

Copyright: © 2013 Kamble P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Etoposide is well-known drug long been used in clinical trials for treating various cancers. The beneficial action of drug can be used in treatment of small cell and non-small cell lung cancer, lymphoma and ovarian cancer. In this study we examined the effect of etoposide on morphological structure of renal tissue. Studies showed that long-term treatment of etoposide given at dose of 1 mg/kg i.p for period of 8 weeks resulted in histological changes that are associated with dilated proximal convoluted tubules (PCT) with enlarged lumen (L) and vacuolation in their epithelium around nucleus. The onset of necrosis and atrophied glomerulus is also observed. Additionally, ultrastructural studies showed presence of mitochondria in segments and lumen with broken microvilli. Furthermore, biochemical finding’s in etoposide treated kidney displayed significant increase in Glutathione-STransferase (GST), Glutathione Peroxidase (Gpx) and decrease in glutathione reductase (GR), gamma glutamyl transpeptidase (GGT) activities however, glutathione (GSH), Catalase (CAT) and Lipid peroxidation (MDA Content) showed non-significant decrease. The drug metabolizing enzyme’s Cytochrome p450 (Cyp450) showed no change whereas, Cytochrome b5 (Cyp b5) showed significant decrease. Thus we conclude that etoposide does not cause nephrotoxic effect at given dose level.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version