Umbilical Cord Blood Hematopoietic Stem Cell Expansion Ex Vivo
- Corresponding Author:
- Yongping Jiang
Biopharmaceutical R&D Center
Chinese Academy of Medical Sciences & Peking Union Medical College
Suzhou, China 215126
E-mail: [email protected]
Received Date: July 22, 2013; Accepted Date: August 07, 2013; Published Date: August 09, 2013
Citation: Ren Z, Jiang Y (2013) Umbilical Cord Blood Hematopoietic Stem Cell Expansion Ex Vivo. J Blood Disord Transfus S3:004. doi:10.4172/2155-9864.S3-004
Copyright: © 2013 Ren Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Umbilical cord blood is an attractive source of hematopoietic stem and progenitor cells in the treatment of hematologic diseases, especially in allogeneic hematopoietic cell transplantation. However, due to the low abundance of these cells, the therapeutic use of umbilical cord blood has been limited mostly to the pediatric setting. The strategies for adult umbilical cord blood transplantation have been improved, with the recent development of various approaches for expanding stem cells in vitro and enhancing their long-term homing efficiency. In this brief review, we discuss a number of strategies for stimulating the proliferation of umbilical cord blood hematopoietic stem cells in vitro, including the utility of transcription factors and growth factors (cytokine cocktails), as well as co-culturing with stromal cells. Ultimately, we make the case that improvements in umbilical cord blood stem cell expansion will be critical for enhancing transplantation engraftment efficacy and providing potential cure for hematological diseases.