Unconventional Vaccines: Progress and Challenges
- *Corresponding Author:
- Nikolai Petrovsky
Flinders Medical Centre and Flinders University
Bedford Park, Adelaide, South Australia
E-mail: [email protected]
Received date: May 14, 2013; Accepted date: May 20, 2013; Published date: May 24, 2013
Citation: Petrovsky N (2013) Unconventional Vaccines: Progress and Challenges. J Vaccines Vaccin 4:186. doi: 10.4172/2157-7560.1000186
Copyright: © 2013 Petrovsky N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
When vaccines are mentioned most people think of immunization against childhood infectious diseases. However, in recent years the uses to which vaccines are being put has dramatically expanded beyond traditional infectious disease applications. Vaccines currently in preclinical and clinical development target prevention or treatment of a wide range of non-infectious diseases including cancer, allergy, asthma, diabetes, rheumatoid arthritis, lupus, hypertension, heart disease, obesity, Alzheimer’s disease, Parkison’s disease and even nicotine and cocaine addiction. For the most part such vaccines aim to induce neutralizing antibodies against foreign or self-antigens, thereby blocking their activity and ability to induce disease. This commentary reviews key clinical advances in the area of unconventional vaccines and identifies some of the key challenges that need to be overcome in order for unconventional vaccines to move forward to medical and commercial success.