alexa Undecaprenyl Pyrophosphate Phosphatase-Encoding Gene in Gram-Positive Bacteria as a New Antimicrobial Target

Immunogenetics: Open Access
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Undecaprenyl Pyrophosphate Phosphatase-Encoding Gene in Gram-Positive Bacteria as a New Antimicrobial Target

Yung-Hua Li1,2* and Xiao-Lin Tian1

1Department of Applied Oral Sciences, Dalhousie University, Halifax, NS, Canada

2Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada

*Corresponding Author:
Yung-Hua Li
5981 University Ave., Rm5215, Faculty of Dentistry
Dalhousie University, Halifax, Nova Scotia, Canada
Tel: (902) 494-3063
Fax: (902) 494-6621
E-mail: [email protected]

Received date: February 24, 2016; Accepted date: March 10, 2016; Published date: March 20, 2016

Citation: Li YH, Tian XL (2016) Undecaprenyl Pyrophosphate Phosphatase-Encoding Gene in Gram-Positive Bacteria as a New Antimicrobial Target . Immunogenet open access 1:103. doi:10.4172/IGOA.1000103

Copyright: © 2016 Li YH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Antimicrobial agents that target bacterial cell wall biosynthesis are among the most successful and effective armamentaria against bacterial infections. However, the worldwide spread of antibiotic resistance in bacteria has eroded the clinical efficiency of these drugs and the antimicrobial pipeline continues to be lean. Nevertheless, cell wall biosynthesis of bacteria remains a high interest and celebrated targets for discovery of novel antimicrobial agents. Recent advances in genomics, including genome-wide mutagenesis analysis, genome sequencing, genotyping and gene expression profiling, have made considerable progress for our understanding of bacterial cell wall synthesis, promoting the discovery of novel antimicrobial targets.

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