Undecaprenyl Pyrophosphate Phosphatase-Encoding Gene in Gram-Positive Bacteria as a New Antimicrobial Target
Received Date: Feb 24, 2016 / Accepted Date: Mar 10, 2017 / Published Date: Mar 20, 2016
Antimicrobial agents that target bacterial cell wall biosynthesis are among the most successful and effective armamentaria against bacterial infections. However, the worldwide spread of antibiotic resistance in bacteria has eroded the clinical efficiency of these drugs and the antimicrobial pipeline continues to be lean. Nevertheless, cell wall biosynthesis of bacteria remains a high interest and celebrated targets for discovery of novel antimicrobial agents. Recent advances in genomics, including genome-wide mutagenesis analysis, genome sequencing, genotyping and gene expression profiling, have made considerable progress for our understanding of bacterial cell wall synthesis, promoting the discovery of novel antimicrobial targets.
Keywords: Antimicrobial agents; Biosynthesis; Mutagenesis
Citation: Li YH, Tian XL (2016) Undecaprenyl Pyrophosphate Phosphatase-Encoding Gene in Gram-Positive Bacteria as a New Antimicrobial Target. Immunogenet open access 1: 103.
Copyright: © 2016 Li YH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Select your language of interest to view the total content in your interested language
Share This Article
- Total views: 8433
- [From(publication date): 3-2016 - Jul 21, 2018]
- Breakdown by view type
- HTML page views: 8341
- PDF downloads: 92