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Under-expression of miR-100 may be a new Carcinogenic pathway for low-grade pTa Bladder Urothelial Carcinomas | OMICS International | Abstract
ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
Open Access

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Research Article

Under-expression of miR-100 may be a new Carcinogenic pathway for low-grade pTa Bladder Urothelial Carcinomas

Nelson Dip1*, Sabrina T. Reis1, Luciana S. Timoszczuk1, Daniel Kanda Abe1,2, Marcos Dall’Oglio2, Miguel Srougi1 and Katia R. M. Leite1

1Laboratory of Medical Investigation, Urology Department – LIM55, University of Sao Paulo Medical School, Sao Paulo, Brazil

2Uro-Oncology Group, Urology Department, Sao Paulo Cancer Institute (ICESP), Sao Paulo, Brazil

*Corresponding Author:
Nelson Gaspar Dip Júnior
Urology Department, Sao Paulo Cancer Institute, Sao Paulo, Brazil
Tel: +55-11-30617183
Fax: +55-11-30617183
E-mail: [email protected]

Received date: November 17, 2011; Accepted date: December 07, 2011; Published date: December 13, 2011

Citation: Dip N, Reis ST, Timoszczuk LS, Abe DK, Dall’Oglio M, et al. (2012) Under-expression of miR-100 may be a new Carcinogenic pathway for low-grade pTa Bladder Urothelial Carcinomas. J Mol Biomark Diagn 3:121. doi: 10.4172/2155-9929.1000121

Copyright: © 2012 Dip N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Abstract

Objectives: The pathways involved in the carcinogenesis of bladder urothelial carcinoma have been well established and are used for the development of new diagnostic and prognostic markers for the disease. The main genetic pathway for the development of low-grade pTa urothelial carcinomas is related to FGFR3 mutation. MicroRNAs have been related to processes involved in carcinogenesis in many organs, and miR-100 was recently shown to target FGFR3 messenger RNA. Our aim was to study the profile of expression of miR-100 and FGFR3 in low-grade, pTa bladder urothelial carcinoma.
Methods and Materials: Using qRT-PCR, we studied the expression of miR-100 and FGFR3 in 30 patients who had undergone transurethral resection of low-grade, pTa bladder urothelial carcinoma.
Results and Conclusion: There was under-expression of miR-100 and over-expression of FGFR3 in 100% of the specimens. Under-expression of miR-100 might be an alternative pathway for low-grade pTa urothelial bladder carcinogenesis and the identification of this molecular alteration may constitute a new diagnostic and prognostic marker for the disease.

Keywords

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