Molecular and Genetic Medicine

Understanding the Biology Behind the EGFR to Improve NSCLC Patients�¢���� Treatment

Abstract

Verlicchi A and Addeo A

Epidermal growth factor receptor (EGFR) is a member of the EGFR tyrosine kinase family, which consists of EGFR (erbB1/Her1), Her2/neu (erbB2), Her3 (erbB3) and Her4 (erbB4). HER receptors are ubiquitously expressed in various cell types, under homeostatic conditions, receptor activation is tightly regulated by the availability of ligands, which collectively form the EGF family.