Unilateral Perisylvian Syndrome and Unilateral Nodular Heteropai: 2 Cases of Neuronal Migration Disorders Presenting as Adulthood Partial Complex Seizures
- *Corresponding Author:
- Canepa Carlo
James Paget University Hospital
Stroke and Neurology, UK
Tel: + 01493 452452
E-mail: [email protected]
Received Date: March 10, 2017 Accepted Date: March 23, 2017 Published Date: March 25, 2017
Citation: Carlo C, Aban D (2017) Unilateral Perisylvian Syndrome and Unilateral Nodular Heteropia: 2 Cases of Neuronal Migration Disorders Presenting as Adulthood Partial Complex Seizures. J Mol Biomark Diagn 8: 332. doi: 10.4172/2155-9929.1000332
Copyright: © 2017 Carlo C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The development of the central nervous system is a complex process, organized in the following steps: primary neurulation (3-4 weeks), prosencephalic development (2-3 months), neuronal proliferation (3-4 months), neuronal migration (3-5 months), organization (5 months of gestation to after birth), and myelination (after birth) . Neuronal migration consists of nerve cells mobilizing from their sites of origin in the ventricular and sub ventricular zones to their final localization. If such process is disrupted, the central nervous system inappropriately develops, manifesting as one of the following five neuronal migration disorders (NMD).