alexa Univariate and Multivariate Analysis of Pathological Prognostic Factors of Urothelial Bladder Cancer in Patients Undergoing Radical Cystectomy and Lymphadenectomy | Abstract
ISSN: 2168-9857

Medical & Surgical Urology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Univariate and Multivariate Analysis of Pathological Prognostic Factors of Urothelial Bladder Cancer in Patients Undergoing Radical Cystectomy and Lymphadenectomy

Endric Hasegawa, Marcos Francisco Dall’Oglio*, Daniel Kanda Abe, Emanoela Batista Feitosa, Alexandre Crippa, José Pontes Junior and Miguel Srougi

Division of Urology of the University of São Paulo Medical School, Section of Uro-Oncology of the São Paulo State Cancer Institute, São Paulo/SP, Brazil

*Corresponding Author:
Marcos F Dall’Oglio
Rua Barata Ribeiro
398-5 andar, CEP 01308-000-São Paulo
SP, Brazil
E-mail: [email protected]

Received date October 11, 2012; Accepted date October 26, 2012; Published date October 28, 2012

Citation: Hasegawa E, Dall’Oglio MF, Abe DK, Feitosa EB, Crippa A, et al. (2012) Univariate and Multivariate Analysis of Pathological Prognostic Factors of Urothelial Bladder Cancer in Patients Undergoing Radical Cystectomy and Lymphadenectomy. Med Surg Urol 1:105. doi:10.4172/2168-9857.1000105

Copyright: © 2012 Hasegawa E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: To identify the most important pathologic prognostic factors for urothelial bladder cancer treated by radical cystectomy and pelvic lymphadenectomy in our institution. To analyze the impact of these factors on recurrence and mortality and suggest a group of factors that can predict the evolution after radical surgery.

Patients and methods: We review all cases of radical cystectomy and lymphadenectomy at the Clinical Hospital Medical School from 2006 to 2009. We study pathologic prognostic factors like tumor stage (pT), lympho-nodal metastasis (N+), lymphovascular invasion (LVI), perineural invasion (PNI) and presence of in situ carcinoma (CIS) and correlates with recurrence and mortality. The chi square, Fisher, log rank and cox regression models were used to determine the significance. We considered a significant association when p<0.05.

Results: From 166 cystectomies performed to treat urothelial bladder cancer, we selected 128 cases. There were 20 (15.6%) females and 108 (84.4%) males with ages ranging from 41 years to 84 years with an average 67 years old. Through univariate analyses, the recurrence was associated with tumor stage (pT) and lympho-nodal metastasis (N+) (p=0.032, p=0.003), but only the latter showed independence in multivariate analysis. (OR 3.2, p=0.003). The pT, N+, lymphovascular invasion (LVI) and perineural invasion (PNI) correlate with early general mortality. The univariate analysis presents the worst overall survival when PNI (p=0.01), pT > pT2 (p=0.001) and N+ (p=0.038). The Kaplan Meier curve found that pT>pT2, N+, LVI and PNI associated with reduced overall survival time. Specific survival time was influenced by pT>pT2 (p=0.001), LVI (p=0.038), N+ (p=0.034), and PNI (p=0.024). The multivariate analysis found that pT>pT2 is the most important prognostic factor associated with specific and overall survival (OR 4.44, p=0.002 and OR 4.28, p=0.001). The grouping of pT, N, LVI and PNI can easily and correct predict recurrence and mortality when compared with current nomograms.

Conclusion: The pathologic prognostic factors after radical cystectomy show that lymphatic metastasis (N+) has a strong association with recurrence and the tumor stage (pT) is a predictor for overall and specific survival. The combination of the factors pT, N, LVI and PNI can be compared to actual nomograms on evolution prediction.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7