alexa Unravelling X-Inactivation through Time: Implications of X-Linked Disorders in Humans | OMICS International | Abstract
ISSN: 2161-0436

Human Genetics & Embryology
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Review Article

Unravelling X-Inactivation through Time: Implications of X-Linked Disorders in Humans

Christalena Sofocleous1,2, Anastasia Kanioura3, Styliani Amenta4, Stavroula Psoni1 and Helen Fryssira1*
1University of Athens Medical School,“Aghia Sophia” Childrens Hospital, Greece
2Research Institute for the Study of Genetic and Malignant disorders in Childhood, Athens, Greece
3Department of Chemistry, University of Athens, Greece
4Styliani Amenta, MD, PhD, Pediatrician, “MITERA” Maternity Hospital, Athens, Greece
Corresponding Author : Helen Fryssira
Assistant Professor in Clinical Genetics
Medical Genetics, University of Athens Medical School
“Aghia Sophia” Childrens Hospital
Goudi, Athens, Greece, P.C.11527
Tel: 302107467459
Fax: +302107795553
E-mail: [email protected]
Received December 01, 2011; Accepted December 27, 2011; Published January 05, 2012
Citation: Sofocleous C, Kanioura A, Amenta S, Psoni S, Fryssira H (2012) Unravelling X-Inactivation through Time: Implications of X-Linked Disorders in Humans. Human Genet Embryol S3:001. doi: 10.4172/2161-0436.S3-001
Copyright: © 2012 Sofocleous C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

X-Inactivation occurs early in embryogenesis, when one of the two chromosomes in each cell is subjected to specific modifications which lead to the formation of the transcriptional inactive heterochromatin known as Barr body. This mechanism was described 50 years ago by Mary Lyon. Scientists have been researching the phenomenon of X- inactivation ever since and multiple factors have been implicated in this multistep procedure. In our review we try to present how some of the mysteries of X- linked disorders in humans have been unraveled through time.

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