Unusual Cause of Severe Aortic Stenosis: Familial Hypercholesterolemia: A Case ReportDioum M1*, Fall L2, Leye M1, Cisse F3, Diagne JP4, Ndao SCT5, Diao M5, Diop IB1 and Kane A6
- *Corresponding Author:
- Dioum M
Cardiology Clinic of CHU Fann, Cheikh Anta Diop University Hôspital
FANN - BP 5534, Dakar, Fann, Senegal
E-mail: [email protected]
Received date: October 06, 2016; Accepted date: November 16, 2016; Published date: December 20, 2016
Citation: Dioum M, Fall L, Leye M, Cisse F, Diagne JP, et al. (2016) Unusual Cause of Severe Aortic Stenosis: Familial Hypercholesterolemia: A Case Report. J Clin Exp Cardiolog 7:490. doi: 10.4172/2155-9880.1000490
Copyright: © 2016 Dioum M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The main etiology of aortic stenosis in Africa is rheumatic fever in middle-age adults. We report the case of an aortic stenosis probably due to familial dyslipidemia. A patient of 24 years, male, was referred by his dermatologist for investigation of exertional dyspnea. Physical examination revealed regular heart sounds with a systolic murmur 4/6 at the aortic valve area and abolition of B2. There was no sign of heart failure. Lipid dosage showed high LDL and total cholesterol levels, 5.42 g/L and 6.23 g/L respectively. Triglyceride and HDL cholesterol levels were normal: 0.70 g/L and 0.62 g/L. Echocardiography found severe aortic stenosis with an aortic valve area of 0.6 cm2; a mean gradient of 68 mmHg and a maximum aortic jet velocity of 5.32 m/s. Coronary angiogram showed slight atheroma but angiographically normal coronary arteries. Dermatological examination showed tuberous xanthomas in pressure areas such as the elbows, knees, and buttocks. Ophthalmologic examination found corneal arcus in both eyes. The patient’s current treatment associated a lipid-lowering diet, statin and diuretics. Although rheumatic heart disease is common in middle-aged adults, aortic stenosis of “atherosclerotic” origin is possible.