alexa Unusual Extramedullary Relapse after Haploidentical Bon
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
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Case Report

Unusual Extramedullary Relapse after Haploidentical Bone Marrow Transplantation in a Patient with Acute Lymphoblastic Leukemiat

Yasuhiro Ebihara1,2*, Shohei Yamamoto1, Shinji Mochizuki1,2, Masao Tsukada3, Yuki Taya3, Aki Sato3, Toshiro Kawakita3, Seiko Kato3, Jun Ooi3, Satoshi Takahashi3, Arinobu Tojo3 and Kohichiro Tsuji1,2,4

1Department of Pediatric Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

2Division of Stem Cell Processing, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

3Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

4National Hospital Organization, Shinshu Ueda Medical Center, Ueda, Japan

*Corresponding Author:
Yasuhiro Ebihara
Department of Pediatric Hematology-Oncology, Research Hospital
Institute of Medical Science, University of Tokyo
4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
Tel: 81-3-5449-5397
Fax: 81-3-5449-5428
E-mail: [email protected]

Received date: July 19, 2013; Accepted date: September 12, 2013; Published date: September 16, 2013

Citation: Ebihara Y, Yamamoto S, Mochizuki S, Tsukada M, Taya Y (2013) Unusual Extramedullary Relapse after Haploidentical Bone Marrow Transplantation in a Patient with Acute Lymphoblastic Leukemia. J Blood Disord Transfus 4:155.doi: 10.4172/2155-9864.1000155

Copyright: © 2013 Ebihara Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Extramedullary relapse of acute lymphoblastic leukemia (ALL) after allogeneic hematopoietic stem cell transplantation (HSCT) is infrequent. In general, the sites of extramedullary relapse are mainly the central nervous system (CNS) and testis, which are so called sanctuary sites. In sites of extramedullary relapse, renal or pancreatic involvements after HSCT are extremely rare in ALL. Here we described a case of 17 year-old male, who was diagnosed as ALL with the t(1;19)/TCF3-PBX1. At twenty months after the fourth myeloablative HSCT, he had extramedullay relapse, which concurrently occurred in pancreas and bilateral kidneys in spite of maintaining hematological complete remission in bone marrow (BM). He had never had extramedullary replaspe including in CNS and testis before this episode. Concurrent involvement of two solid organs (pancreas and kidney) after HSCT as in the present case has not been described.

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