Update on Genetics of Leprosy
Susilene Maria Tonelli-Nardi1*, Carla Renata Graça2 and Vânia Del´ArcoPaschoal3
1 Centro de Laboratório Regional – Instituto Adolfo Lutz - São José do Rio Preto, São Paulo, Brasil
2 Laboratório de Investigação Neuromuscular- LIN, Faculdade de Medicina de São José do Rio Preto, São Paulo, FAMERP, Brasil
3 Profa. Dra. Adjunta do departamento de enfermagem, Faculdade de Medicina de São José do Rio Preto, São Paulo, FAMERP, Brasil
- *Corresponding Author:
- Susilene Maria Tonelli Nardi
Centro de Laboratório Regional – Instituto Adolfo Lutz - São José do Rio Preto, São Paulo, Brasil
E-mail: [email protected]
Received Date: June 27, 2013; Accepted Date: April 08, 2014; Published Date: April 10, 2014
Citation: Tonelli-Nardi SM, Graça CR, Paschoal VD (2014) Update on Genetics of Leprosy. J Anc Dis Prev Rem 2:109. doi: 10.4172/2329-8731.1000109
Copyright: © 2014 Tonelli-Nardi SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae that mainly infects skin macrophages and Schwann cells in peripheral nerves. Genetic and environmental factors play an important role in leprosy. It is estimated that approximately 90% of the population develop protective immunity in infection, and, therefore, do not get sick. Other individuals, however, show clinical susceptibility to a wide spectrum of pathogens associated to changes in immune response. Data observed in various populations show that some aspects related to disease progression are due to host genetic factors that influence control of the initial infection and the host immune response to that infection. Nevertheless, individual genetic factors have a strong influence on the acquisition of or protection against leprosy, since the limited genetic diversity observed among M. leprae strains is not a significant factor for the development and the clinical course of disease.