Up-Regulating Telomerase and Tumor Suppression: A Two-Step Strategy to Boost Hematopoietic Stem Cell TransplantationFernando Pires Hartwig*
Postgraduate Program in Epidemiology, Department of Social Medicine, Faculty of Medicine, Federal University of Pelotas, Brazil
- *Corresponding Author:
- Fernando Pires Hartwig
Postgraduate Program in Epidemiology
Department of Social Medicine
Faculty of Medicine
Federal University of Pelotas, Brazil
Tel: (5553) 81347172
E-mail: [email protected]
Received date: July 02, 2013; Accepted date: September 11, 2013; Published date: September 13, 2013
Citation: Hartwig FP (2013) Up-Regulating Telomerase and Tumor Suppression: A Two-Step Strategy to Boost Hematopoietic Stem Cell Transplantation. J Stem Cell Res Ther S3:003. doi:10.4172/2157-7633.S3-003
Copyright: © 2013 Hartwig FP. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The high levels of morbidity and mortality of chronic non-communicable diseases (most of which highly associated with aging) worldwide indicate the need of studying the underlying mechanisms of physiological aging and aging related-impairments and the development and improvement of therapeutic approaches such as cell therapy. In this manuscript, two well-established aging mechanisms – telomere shortening and DNA damage accumulation – are briefly reviewed regarding their roles in hematopoietic stem cells function and transplantation. Based on the available literature, up-regulating both telomerase and tumor suppressors is proposed in a two-step strategy as a promising mechanism to benefit hematopoietic stem cell transplantation qualitatively (by enriching the cell pool for healthy hematopoietic stem cells) and qualitatively (by in vitro expansion of healthy hematopoietic stem cells). The applications, limitations and perspectives associated with the proposed strategy are also discussed.