Urinary Neutrophil Gelatinase Associated Lipocalin and Interleukin-18 as Early Predictors of Kidney Injury in Neonates
- *Corresponding Author:
- Mohamed S El Frargy
Departments of Pediatrics
Faculty of Medicine
Tanta University, Egypt
Tel: +20 40 3452372
E-mail: [email protected]
Received Date: July 25, 2016; Accepted Date: September 22, 2016; Published Date: September 25, 2016
Citation: El Frargy MS, Soliman NA (2016) Urinary Neutrophil Gelatinase Associated Lipocalin and Interleukin-18 as Early Predictors of Kidney Injury in Neonates. J Mol Biomark Diagn 8:308. doi: 10.4172/2155-9929.1000308
Copyright: © 2016 El Frargy MS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Early detection of renal affection in neonates is vital for early treatment and prevention of dangerous complications, so the using of some markers like urinary neutrophil gelatinase associated lipocalin (uNGAL), interleukin-18 (uIL-18) is very important as the commonly used detectors as creatinine are very late.
Patient and methods: This study included 80 neonates and was carried out at neonatal intensive care unit (NICU), pediatrics department, Tanta university hospital, Egypt from 6/2013 to 6/2015. Group 1 (kidney injury-patient group): This group included forty neonates Group 2 (Control Group): This group included forty healthy neonates from outpatient clinic. uNGAL, uIL-18 and serum creatinine were assessed in 80 neonates at day 1 and day 3 of neonatal intensive care unit admission who had renal affection later proved by BUN serum creatinine.
Results: Means of uNGAL, uIL-18 and serum creatinine in the day 1 of admission in cases and control groups were (30.94 ± 10.05 vs 6.7 ± 4.49), (11.61 ± 9.00 vs 1.1.98 ± 1.18) and (0.64 ± 0.17 vs 0.59 ± 0.19) respectively with p-value <0.05 which was significant in uNGAL and uIL-18 only.
Conclusions: uNGAL and uIL-18 are considered simple and accurate markers in early detection of renal impairment in neonates which are better than serum creatinine