alexa
Reach Us +1-504-608-2390
Urine Neutrophil Gelatinase-Associated Lipocalin (uNGAL) in Lupus Nephritis: A Prospective Longitudinal Study | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article

Urine Neutrophil Gelatinase-Associated Lipocalin (uNGAL) in Lupus Nephritis: A Prospective Longitudinal Study

Sabah Alharazy1*, Norella CT Kong1, Marlyn Mohd2, Shamsul A Shah3, Arbaiyah Ba´in1 and Abdul Halim Abdul Gafor1
1Nephrology Unit, Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
2Department of Medical Microbiology & Immunology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
3Department of Community Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
Corresponding Author : Dr. Sabah Mohamed Alharazy
Nephrology Unit, Department of Medicine
Pusat Perubatan Universiti Kebangsaan Malaysia
Jalaln Yaacob Latif, Bandar Tun Razak
56000 Cheras, Kuala Lumpur, Malaysia
Tel: +603-91456939
Fax: +603-91735316
E-mail: [email protected]
Received February 13, 2014; Accepted May 13, 2014; Published May 20, 2014
Citation: Alharazy S, Kong NCT, Mohd M, Shah SA, Ba´in A, et al. (2014) Urine Neutrophil Gelatinase-Associated Lipocalin (uNGAL) in Lupus Nephritis: A Prospective Longitudinal Study. J Clin Cell Immunol 5:214. doi:10.4172/2155-9899.1000214
Copyright: © 2014 Alharazy S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google

Abstract

Objective: Urine neutrophil gelatinase-associated lipocalin (uNGAL) is increased in active lupus nephritis (LN). In this longitudinal study, we further evaluated the role of uNGAL as a potential marker for monitoring LN response to treatment and/or early relapse.
Methods: uNGAL levels were measured at baseline and at 2- and 4-months in 100 patients with biopsy-proven LN. They were divided into 2 groups - active LN [non-remission (NR) and relapses] and inactive LN [complete remission (CR) or partial remission (PR)]. Renal function test, urinary parameters, lupus serology and renal SLE disease activity index-2K (renal SLEDAI-2K) were analyzed to determine their associations with uNGAL.
Results: At baseline, there were 47 patients in the active group (42 NR and 5 relapsed) and 53 in the inactive group (51 CR and 2 PR). With treatment, the number with active LN declined to 29 (27 NR and 2 Relapsed) at 2 months and 22 (16 NR and 6 Relapsed) at 4 months respectively. Conversely, the number in the inactive group increased to 71 (61 CR and 10 PR) at 2 months and 78 (59 CR and 19 PR) at 4 months respectively. At each visit, uNGAL levels (ng/mg creatinine) were significantly higher in the active group especially relapses and were significantly associated with proteinuria and renal SLEDAI-2K. Receiver operating characteristic (ROC) curves showed that uNGAL was a potential biomarker for LN. Nonetheless, multiple logistic regression analysis showed that only serum albumin and proteinuria and not uNGAL were independent predictors of LN activity.
|Conclusions: uNGAL was increased in active LN especially flares. Although not an independent predictor for LN activity, uNGAL could serve as an adjunctive marker when the clinical diagnosis of LN especially early relapse remains uncertain. Larger and longer studies are indicated.

Keywords

Top