Use of Annexin V based Sperm Selection in Assisted ReproductionTeijeiro Juan Manuel1, Munuce María José1, Caille Adriana María1, Zumoffen Carlos1 and Marini Patricia Estela1,2*
- *Corresponding Author:
- Marini Patricia Estela
Laboratory of Cytogenetics, Laboratory of Reproductive Medicine
Biochemical and Pharmaceutical Sciences, National University of Rosario, Argentina
E-mail: [email protected]
Received date: May 11, 2017; Accepted date: May 18, 2017; Published date: May 25, 2017
Citation: Manuel TJ, José MM, María CA, Carlos Z, Estela MP (2017) Use of Annexin V based Sperm Selection in Assisted Reproduction. Andrology (Los Angel) 6:1000182. doi:10.4172/2167-0250.1000182
Copyright: © 2017 Manuel TJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Innovative methods to select sperm subpopulations with the best fertilizing ability are needed in assisted reproductive techniques (ART) in order to improve fertilization and pregnancy rates, while also considering possible epigenetic effects on the offspring. Molecular based selection methods are searched for, under the premise that they could be an improvement over classical selection by morphology and movement. One of these methods sustains the elimination of sperm that can bind to annexin A5 (ANX V), coupled to paramagnetic beads, through the phosphatidyl-serine exposed on their membranes upon apoptosis. Although reports accumulate about the use of this method, controversy persists as to the benefits of ANX V based sperm selection in ART. In this review we consider the arguments in favour and against this method and conclude that to the moment the evidence does not support MACS regular use in ART.