Use of Basophil Activation Test in a Case of Oxaliplatin Hypersensitivity
Received date: November 21, 2010; Accepted date: January 20, 2011; Published date: January 22, 2011
Citation: Jean-Luc H (2011) Use of Basophil Activation Test in a Case of Oxaliplatin Hypersensitivity. J Aller Ther 2:108. doi: 10.4172/2155-6121.1000108
Copyright:© 2011 Jean-Luc H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Up to now, oxaliplatin hypersensitivity diagnosis relies upon an evocative clinical history and a confirmation by skin tests, especially intradermal tests. We report here a case of anaphylactic reaction to oxaliplatin. Besides the usual in vivo tests, we applied the basophil activation test (BAT) to confirm the diagnosis. Concordance between BAT and skin tests results suggests the usefulness of the in vitro test as diagnostic tool in drugs hypersensitivity. Further studies will be required to standardize BAT in this indication.