Use of Pharmacogenetic Testing in Routine Clinical Practice Improves Outcomes for Psychiatry PatientsTimothy Ramsey1,2*, Elizabeth Griffin3, Qian Liu4, Mark D Brennan1 and Sandeep Vaishnavi3,5
- *Corresponding Author:
- Timothy Ramsey
Head of Behavioral Health
Clinical Reference Laboratory
600 Envoy Circle, Louisville
KY 40299, USA
E-mail: [email protected]
Received Date: November 14, 2015; Accepted Date: July 06, 2016; Published Date:July 13, 2016
Citation: Ramsey T, Griffin E, Liu Q, Brennan MD, Vaishnavi S (2016) Use of Pharmacogenetic Testing in Routine Clinical Practice Improves Outcomes for Psychiatry Patients? J Psychiatry 19:377. doi:10.4172/2378-5756.1000377
Copyright: © 2016 Ramsey T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Introduction: In clinical trials, pharmacogenetic testing has been shown to improve outcomes in psychiatric patients. It is unclear if these improved outcomes translate into routine clinical practice. A significant impediment to evaluation of pharmacogenetics testing in routine practice has been a lack of quantifiable outcomes data. This study leverages longitudinal symptom evaluations using validated computer-based assessments to evaluate the impact of pharmacogenetic testing across a number of psychiatric symptom dimensions in routine clinical practice.
Methods: This study retrospectively evaluated data from The Neuropsychiatric Clinic, Carolina Partners, Raleigh, NC who were either tested (n=74) or untested (n=57) with a commercial genetic test at physician’s discretion. All subjects had at least four evaluations with the NeuroPsych Questionnaire-Short Form. Treatment effects were estimated using a general linear model incorporating all time points and baseline values for the 12 NPQ individual items.
Results: Tested patients experienced significantly greater improvement over time in a number of symptom dimensions. Aggression, anxiety, depression, fatigue, impulsivity, mood instability, panic, and suicide symptoms improved more in tested patients compared to untested patients (p=10-8 to 10-20).
Conclusions: In routine clinical practice, pharmacogenetic testing can enable significant improvement in clinically outcomes for psychiatric patients with a variety of diagnoses.