Use of Silica-Gold Core Shell Structured Nanoparticles for Targeted Drug Delivery System
- *Corresponding Author:
- Dr. Thangaraja Amirthalingam
Department of Biotechnology
St Peter’s University
Avadi, Chennai, Tamilnadu, India
E-mail: [email protected]
Received Date: August 29, 2011; Accepted Date: November 14, 2011; Published Date: November 16, 2011
Citation: Amirthalingam T, Kalirajan J, Chockalingam A (2011) Use of Silica- Gold Core Shell Structured Nanoparticles for Targeted Drug Delivery System. J Nanomedic Nanotechnol 2:119. doi:10.4172/2157-7439.1000119
Copyright: © 2011 Amirthalingam T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Drug targeting, using Silica-Gold core carrier particles loaded with antibiotic drugs is an emerging and significant method of disease treatment. Silica core particles were synthesized by Stober’s method and it was functionalized with amine groups. The monodispersed Gold particles were prepared by conventional citrate reduction method. Both functionalized Silica and monodispersed Gold nanoparticles were combined and Silica-Gold core nanoshells was prepared in the range of 60-110nm. The morphology, elemental composition of the core nanoshell was characterized by UV-Visible spectroscopy, FT-IR spectroscopy, Scanning Electron Microscope (SEM), Energy Diffusive Spectroscopy (EDX) and X-ray Diffraction analysis. The antibiotic Gentamycin was loaded onto these Silica-Gold core nanoshell carriers and the drug release profile was observed.