alexa Usefulness of Α-Lipoc Acid, Leucoselect and Ginkgoselect Phytosoma in Chronic Venous Insufficiency
ISSN: 2329-9495

Angiology: Open Access
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Research Article

Usefulness of Α-Lipoc Acid, Leucoselect and Ginkgoselect Phytosoma in Chronic Venous Insufficiency

Luca Costanzo1*, Antonino Grasso2, Corrado Tamburino1 and Luigi Di Pino1

1Cardio-Thoraco-Vascular Department, Division of Angiology, Ferrarotto-Policlinic Hospital, University of Catania, Catania, Italy.

2Cardio-Thoraco-Vascular Department, Unit of Vulnology, Policlinic Hospital, University of Catania, Catania, Italy.

Corresponding Author:
Luca Costanzo
Cardio-Thoraco-Vascular Department
Division of Angiology, Ferrarotto-Policlinic Hospital
University of Catania, Catania, Italy
Tel: 39 3384486289
Fax: 390953782743
E-mail: [email protected]

Received Date: April 19, 2016; Accepted Date: June 07, 2016; Published Date: June 15, 2016

Citation: Costanzo L, Grasso A, Tamburino C, Pino DL (2016) Usefulness of Α-Lipoc Acid, Leucoselect and Ginkgoselect Phytosoma in Chronic Venous Insufficiency. Angiol 4:174. doi:10.4172/2329-9495.1000174

Copyright: © 2016 Costanzo L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Background: Chronic venous insufficiency (CVI) is a frequent pathology that affects quality of life of the patients due to several symptoms such as pain, leg cramps, aching and itch. Our scope was to verify the usefulness of a supplement based on α-lipoc acid, Leucoselect® and Ginkgoselect® phytosome in patients with CVI. Methods: From July to November 2015, 30 consecutive patients with CVI received once a day a tablet containing the supplement for a period of 4 weeks. A control group of 30 subjects taking placebo and matched for CVI class, age and sex was also recruited. Clinical evaluation using VCSS and microcirculatory assessment with perimalleolar capillaroscopy were performed. A questionnaire consisting of two questions investigating presence of pain and itch/ paraesthesia was also given to the patients. Each question was scored on a dichotomous Likert scale (0=no; 1=yes). Results: A significant reduction of VCSS from baseline to 4-weeks was observed in the group of treatment respect to control group (2.70 ± 0.95 vs 0.93 ± 0.74 and 2.87 ± 0.86 vs 2.60 ± 0.81, p<0.0001). Itch and paresthesias resolved in 86.7% of patients vs 26.7% of control (p<0.0001) while leg pain improved in 70% of cases vs 23.3% of control (p<0.001). No significant changes were found between baseline and 4-weeks capillaroscopic pattern in both groups. Conclusions: After 4-weeks of treatment with α-lipoc acid, leucoselect and ginkgoselect phytosoma we observed clinical improvement of CVI symptoms, especially itch and paresthesias.


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