alexa Using the Drosophila melanogaster to Assessment Carcino
ISSN: 2379-1764

Advanced Techniques in Biology & Medicine
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Review Article

Using the Drosophila melanogaster to Assessment Carcinogenic Agents through the Test for Detection of Epithelial Tumor Clones (Warts)

Júlio César Nepomuceno*
Centro Universitário de Patos de Minas, Laboratório de Citogenética e Mutagênese, Patos de Minas, Minas Gerais, Brazil
Universidade Federal de Uberlândia, Instituto de Genética e Bioquímica, Uberlândia, Minas Gerais, Brazil
Corresponding Author : Júlio César Nepomuceno
Centro Universitário de Patos de Minas
Laboratório de Citogenética e Mutagênese, Patos de Minas
Minas Gerais, Brazil
Tel: +55343823-0169
E-mail: [email protected]
Received: September 25, 2015; Accepted: October 23, 2015; Published: October 30, 2015
Citation: Nepomuceno JC (2015) Using the Drosophila melanogaster to Assessment Carcinogenic Agents through the Test for Detection of Epithelial Tumor Clones (Warts). Adv Tech Biol Med 3:149. doi: 10.4172/2379-1764.1000149
Copyright: © 2015 Nepomuceno JC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Genetic toxicology testing has initially concentrated on induction of gene mutations and chromosome aberrations because these genetic changes are considered of great importance for it induces heritable diseases as well as the initiation of cancer. The classical studies on the genetic events underlying the development of tumors proved the importance of phenomenon termed “loss of heterozygosity”. Gene conversion and, mitotic recombination are potent mechanisms leading to loss of heterozigosity. The most important is that the step of induced loss of heterozygosity may be an early or a late step in carcinogenesis. During early embryonic development, groups of cells (imaginal discs) are set apart. They proliferate mitotically during the larval development until they differentiate during metamorphosis into structures of the body of the adult fly (eyes, wings). If a genetic alteration occurs in one of these imaginal disc cells, this alteration will be present in all the descendant cells and will form a clone of mutant cells. The wts (warts) gene was identified based on its ability to act as a tumor suppressor in Drosophila. Deletion, recombination of this gene leads to the formation of cells clones that are rounded and greatly overgrown, and literally generate “warts” (tumors) on their body. This system test will be a useful additional genetic endpoint in toxicological studies in general, as well as in studies to evaluate carcinogenic agents.

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