alexa Using Topical Applications of Tamoxifen and a Combination of Phytonutrients Based on Breast MRI to Inhibit Estrogen-Related Proliferation of Human Breast Tissue
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Using Topical Applications of Tamoxifen and a Combination of Phytonutrients Based on Breast MRI to Inhibit Estrogen-Related Proliferation of Human Breast Tissue

Shoei-Loong Lin1, Cheuk-Sing Choy2, Wing P Chan3 and Ting-Kai Leung3,4*

1Department of Surgery, Taipei Hospital, Ministry of health and Welfare, Taiwan., R.O.C and Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taiwan

2Emergency and intensive care department, Taipei Hospital, Department of Health, Taiwan

3Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University and Department of Radiology, Wan Fang Hospital, Taipei Medical University, Taiwan

4Diagnostic Radiology department, Taipei Hospital, Ministry of Health and Welfare, Taiwan

*Corresponding Author:
Ting Kai Leung
Department of Radiology, Taipei Hospital
Ministry of Health and Welfare, NO.127, Su Yuan Road
Hsin Chuang District, New Taipei City, 242-13, Taiwan
Tel: 886-2-22765566+2187
Fax: 886-2-22765591
E-mail: [email protected]

Received date: December 03, 2013; Accepted date: January 07, 2014; Published date: January 13, 2014

Citation: Lin SL, Choy CS, Chan WP, Leung TK (2014) Using Topical Applications of Tamoxifen and a Combination of Phytonutrients Based on Breast MRI to Inhibit Estrogen-Related Proliferation of Human Breast Tissue. Pharm Anal Acta 5:281. doi: 10.4172/2153-2435.1000281

Copyright: © 2014 Lin SL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective: In January of 2013, the National Institute of Health and Clinical Excellence of United Kingdom have announced that taking tamoxifen for five years could reduce breast cancer risk, include positive family history or chronic estrogen and phytoestrogen users. However, routinely oral intake of tamoxifen for breast cancer prophylaxis on high risk women is occasionally difficult because of its potential side effects. The intention of this study is to prove transdermal delivery by using minimal dose of tamoxifen and phytonutrients for breast protection. Methods: We retrospectively studied 2795 breast MRI images from Taiwanese women and classified them as either healthy or unhealthy according to BI-RADS categories. A subgroup of the study patients had received estrogen supplements containing estrogen components or phytoestrogen for at least 3 months. Based on breast MRI analysis, these 2 groups were compared and found significant different. The overuse of estrogen or phytoestrogen supplements can increase breast glandular tissue proliferation, as reflected in MRI images. Such proliferation may increase the risk of future breast cancer. We also studied the efficacy of tamoxifen and the phytonutrients to inhibit proliferation of mammary glandular cell, as well as their transdermal absorption in animal models. Results: We demonstrated cell proliferative change of normal breast cells (MCF-10a) under estrogen treatment. For studied of transdermal absorption by topical application, we used Franz cell with artificial skin membrane to demonstrate positive transdermal diffusion using animal urine/feces, blood samples and subcutaneous skin retention for HPLC analysis. Conclusion: We successful demonstrate the transdermal absorption of topical application of tamoxifen and phytonutrients; it may help to reduce breast cancer development in regular estrogen and phytoestrogen users.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords