alexa Uterine Cervix Metastasis as an Initial Manifestation of Metastatic Renal Cell Carcinoma: A Case Report and Review of Literature | OMICS International | Abstract
ISSN: 2155-9619

Journal of Nuclear Medicine & Radiation Therapy
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Case Report

Uterine Cervix Metastasis as an Initial Manifestation of Metastatic Renal Cell Carcinoma: A Case Report and Review of Literature

Muhannad AlArifi1, Khalid Riaz2, Mutahir Ali Tunio2* and Mushabbab Al Asiri3

1Muhannad AlArifi, King Saud bin AbdulAziz University for Health Sciences, Riyadh 11345, Saudi Arabia

2Khalid Riaz, Radiation Oncology, Comprehensive Cancer Centre, King Fahad Medical City (KFMC), Riyadh 59046, Saudi Arabia

3Mushabbab Al Asiri, Director Comprehensive Cancer Center, Chairman Radiation Oncology, King Fahad Medical City, Riyadh-59046, Saudi Arabia

*Corresponding Author:
Mutahir Tunio
Assistant Consultant
Radiation Oncology, Comprehensive Cancer Centre
King Fahad Medical City (KFMC), Riyadh 59046, Saudi Arabia
Tel: +966 1 2889999
Fax: 966 1 4614006
E-mail: [email protected]

Received date: June 23, 2012; Accepted date: July 17, 2012; Published date: July 20, 2012

Citation: AlArifi M, Riaz K, Tunio MA, Asiri MA. (2012) Uterine Cervix Metastasis as an Initial Manifestation of Metastatic Renal Cell Carcinoma: A Case Report and Review of Literature. J Nucl Med Radiat Ther S6:011. doi: 10.4172/2155-9619.S6-011

Copyright: © 2012 AlArifi M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Renal cell carcinoma (RCC) has unpredictable and diverse behaviour. The classic triad of hematuria, loin pain and abdominal mass is uncommon at time of presentation. About 25%-30% of patients are found to have metastases at the time of diagnosis. Bones, lungs, liver and brain are the frequent sites of metastases. RCC with metastasis to the cervix uteri is rarest manifestation and only four case reports have been published so far.

Case Presentation: Herein we present a case of 70 year old Saudi female presenting with 4 months history of vaginal bleeding and weight loss. Her past medical history revealed left sided radical nephroectomy for RCC. She had no other co-morbidities. On physical examination, she was found emaciated and per vaginal examination showed fragile fungating mass of cervix. The punch biopsy of cervical mass confirmed the diagnosis of metastatic RCC. Further, staging workup showed bilateral pulmonary metastasis. She was given palliative Radiotherapy 30 Gy in 10 fractions followed by Sunitinib 50 mg oral daily, but patient died of progressive disease 4 months of palliative radiotherapy.

Conclusion: Metastatic RCC to cervix uteri is very rare manifestation. The physicians should consider metastasis from another primary as the differential diagnosis in order to plan optimal treatment. Reported treatment is radical hysterectomy with bilateral salpingo-oophorectomy followed by Tyrosine Kinase Inhibitors (TKIs). Patients who are not candidate for surgery; radiotherapy and TKIs is a reasonable option.

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