Uterine Cervix Metastasis as an Initial Manifestation of Metastatic Renal Cell Carcinoma: A Case Report and Review of LiteratureMuhannad AlArifi1, Khalid Riaz2, Mutahir Ali Tunio2* and Mushabbab Al Asiri3
- *Corresponding Author:
- Mutahir Tunio
Radiation Oncology, Comprehensive Cancer Centre
King Fahad Medical City (KFMC), Riyadh 59046, Saudi Arabia
Tel: +966 1 2889999
Fax: 966 1 4614006
E-mail: [email protected]
Received date: June 23, 2012; Accepted date: July 17, 2012; Published date: July 20, 2012
Citation: AlArifi M, Riaz K, Tunio MA, Asiri MA. (2012) Uterine Cervix Metastasis as an Initial Manifestation of Metastatic Renal Cell Carcinoma: A Case Report and Review of Literature. J Nucl Med Radiat Ther S6:011. doi: 10.4172/2155-9619.S6-011
Copyright: © 2012 AlArifi M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Renal cell carcinoma (RCC) has unpredictable and diverse behaviour. The classic triad of hematuria, loin pain and abdominal mass is uncommon at time of presentation. About 25%-30% of patients are found to have metastases at the time of diagnosis. Bones, lungs, liver and brain are the frequent sites of metastases. RCC with metastasis to the cervix uteri is rarest manifestation and only four case reports have been published so far.
Case Presentation: Herein we present a case of 70 year old Saudi female presenting with 4 months history of vaginal bleeding and weight loss. Her past medical history revealed left sided radical nephroectomy for RCC. She had no other co-morbidities. On physical examination, she was found emaciated and per vaginal examination showed fragile fungating mass of cervix. The punch biopsy of cervical mass confirmed the diagnosis of metastatic RCC. Further, staging workup showed bilateral pulmonary metastasis. She was given palliative Radiotherapy 30 Gy in 10 fractions followed by Sunitinib 50 mg oral daily, but patient died of progressive disease 4 months of palliative radiotherapy.
Conclusion: Metastatic RCC to cervix uteri is very rare manifestation. The physicians should consider metastasis from another primary as the differential diagnosis in order to plan optimal treatment. Reported treatment is radical hysterectomy with bilateral salpingo-oophorectomy followed by Tyrosine Kinase Inhibitors (TKIs). Patients who are not candidate for surgery; radiotherapy and TKIs is a reasonable option.