alexa Utility of Ion-associate Formation Reactions for the Sp
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Research Article

Utility of Ion-associate Formation Reactions for the Spectrophotometric Determination of Sildenafil Citrate in Pure form and in Virecta Tablets

Eman Y.Z. Frag, Gehad G. Mohamed* and Hana M.S. Alelaiwi

Chemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt

*Corresponding Author:
Dr. Gehad G. Mohamed
Chemistry Department, Faculty of Science
Cairo University, Giza, 12613, Egypt
Tel: +2 012 3060262
E-mail: [email protected]

Received date: June 13, 2011; Accepted date: August 18, 2011; Published date: August 20, 2011

Citation: Frag EYZ, Mohamed GG, Alelaiwi HMS (2011) Utility of Ion-associate Formation Reactions for the Spectrophotometric Determination of Sildenafil Citrate in Pure form and in Virecta Tablets. Pharm Anal Acta 2:131. doi: 10.4172/2153-2435.1000131

Copyright:© 2011 Frag EYZ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

A simple, rapid and sensitive extractive spectrophotometric method has been developed for the assay of sildenafil citrate (SILC) in pure and pharmaceutical formulations (Virecta tablets). This method is based on the formation of chloroform soluble ion-pair of SILC with bromothymol blue (BTB) and methylene chloride soluble ion- pair of SILC with bromophenol blue (BPB) and eriochrome blue black R (EBBR) in borax buffer of pH 3 and volume 1mL for BTB while acetate buffer of pH 3 and volume 1mL for BPB and universal buffer of pH 2 and volume 1.5 mL for EBBR with absorption maximum at 415, 420 nm and 510 nm for BTB, BPB and EBBR reagents, respectively. Reaction conditions were optimized to obtain the maximum colour intensity. The absorbance was found to increase linearly with the increase in SILC concentration, which was corroborated by the calculated correlation coefficient values (0.9909, 0.9901 and 0.9917 for BTB, BPB and EBBR reagents, respectively). The systems obeyed Beer’s law over the concentration range of 1-40, 1-50 and 3-70 μg mL -1 for BTB, BPB and EBBR, respectively. Various analytical parameters have been evaluated and the results have been validated by statistical data. No interference was observed from common excipients present in pharmaceutical formulations.

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