alexa Utilization Assessment of Surgical Antibiotic Prophylaxis at Ayder Referral Hospital, Northern Ethiopia
ISSN: 1920-4159

Journal of Applied Pharmacy
Open Access

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Research Article

Utilization Assessment of Surgical Antibiotic Prophylaxis at Ayder Referral Hospital, Northern Ethiopia

Said Aden Mohamoud1, Teshager Aklilu Yesuf 2 and Eskinder Ayalew Sisay3*

1Faculty of Health Sciences, Global Science University, Galkaio - Puntland, Somalia

2Department of Pharmacy, College of Health Sciences, Wollo University, Dessie, Ethiopia

3Department of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

*Corresponding Author:
Eskinder Ayalew Sisay
Department of Pharmacy, College of Health Sciences
Mekelle University, P.O.Box 1871, Ayder Referral Hospital, Mekelle, Ethiopia
Tel: +251910072107
E-mail: [email protected]

Received date: March 24, 2016; Accepted date: April 22, 2016; Published date: April 27, 2016

Citation: Mohamoud SA, Yesuf TA, Sisay EA (2016) Utilization Assessment of Surgical Antibiotic Prophylaxis at Ayder Referral Hospital, Northern Ethiopia. J App Pharm 8:220. doi: 10.4172/1920-4159.1000220

Copyright: © 2016 Mohamoud SA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Introduction: Surgical site infection represents a significant burden in terms of patients’ morbidity, mortality and hospital costs which can be prevented using prophylaxis.

Objective: To assess rate of compliance to Surgical Antibiotic Prophylaxis (SAP) guidelines at Ayder Referral Hospital (ARH).

Method: Prospective cross-sectional study was conducted from 12th March to 28thApril, 2015. Data were collected using data abstraction checklist for all patients who underwent surgery and met inclusion criteria. SAP Guidelines and CDC Wound Classification were used as data assessment protocols. Epidata 3.1 and SPSS 16 were used for data entry and analysis of descriptive statistics.

Results: A total of 196 patients with mean age of 37.84 years were recruited (female, 58.7%). Of these, 62.2% received SAP but prophylaxis was needed in 58.2%. The total compliance to SAP guideline was 21.9% and 25% for national Standard Treatment Guideline (STG) and American Society of Health-system Pharmacist (ASHP) guideline respectively. Selection of SAP (national STG 100% versus ASHP Guideline 89.5%) was the most deviated parameter from SAP guidelines followed by duration (63.5%), indication (19.4%) and dose (10.4%). Most commonly used agent was ceftriaxone (85.2%).

Conclusion: Current practice of ARH is hugely divergent from SAP guidelines. Use of broader spectrum antibiotics for extended period was common.


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