Utilization of Crosslinked Starch Nanoparticles as a Carrier for Indomethacin and Acyclovir DrugsGina S El-Feky2, El-Rafie MH1, MA El-Sheikh1, Mehrez E El-Naggar1* and Hebeish A1
- *Corresponding Author:
- Mehrez E El-Naggar
Textile Research Division
National Research Centre, Cairo, Egypt
E-mail: [email protected]
Received Date: July 14, 2014; Accepted Date: December 16, 2014; Published Date: January 01, 2015
Citation: El-Feky GS, El-Rafie MH, El-Sheikh MA, El-Naggar ME, Hebeish A (2015) Utilization of Crosslinked Starch Nanoparticles as a Carrier for Indomethacin and Acyclovir Drugs. J Nanomed Nanotechnol 6:254 doi:10.4172/2157-7439.1000254
Copyright: © 2015 El-Feky GS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
An eco-friendly nanoprecipitation technique was put forward to synthesize native starch nanoparticles loaded with insoluble drugs such as indomethacin (IND) and Acyclovir (ACV). Factors studied to find out the optimum conditions for preparation of different formulations of crosslinked starch nanoparticles (TPP-StNPs) loaded with insoluble drugs. The factors are 20 mg, 50 mg of drug concentration and 0.5, 1 g of sodium tripolyphosphate (STPP) while the concentration of starch and surfactant were kept constant. World-class facilities as particle size analyzer, poly dispersity index (PDI), zeta potential, TEM, XRD, FT-IR, UV-vis spectroscopy and DSc were used for evaluation of the resultant crosslinked starch nanoparticles loaded with drug. The sustained release of drugs were evaluated using entrapment efficiency and in vitro release. The data obtained confirmed that there is no chemical interaction between drug (IND, ACV) and crosslinked starch nanoparticles. The results indicate that the best formula for IND loaded starch nanoparticles was 0.5 g STPP and 20 mg IND while the best formula for ACV nanoparticles was at 0.5 g STPP and 50 mg ACV drug.