alexa Vaccine Strategies against Human Papillomavirus: A Discussion Focused on Developing Countries
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Review Article

Vaccine Strategies against Human Papillomavirus: A Discussion Focused on Developing Countries

Antonio Carlos de Freitas*, Filipe Colaço Mariz, Eliane Campos Coimbra, Marcelo Nazário Cordeiro and André Luiz Santos de Jesus
Laboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Center of Biological Science, Universidade Federal de Pernambuco, Rua Prof. Nelson Chaves s/n, Cidade Universitária 50732-970, Recife – PE, Brazil
Corresponding Author : Antonio Carlos de Freitas
Laboratory of Molecular Studies and Experimental Therapy
Department of Genetics, Center of Biological Science
Universidade Federal de Pernambuco
Cidade Universitária 50732-970 Recife – PE, Brazil
Tel: (81) 21268520 and (81) 2126-8569
Fax: (81) 2126-8522
E-mail: [email protected]; [email protected]
Received November 11, 2011; Accepted January 05, 2012 Published January 07, 2012
Citation: Freitas AC, Mariz FC, Coimbra EC, Cordeiro MN, Jesus ALS (2012) Vaccine Strategies against Human Papillomavirus: A Discussion Focused on Developing Countries. J Clin Cell Immunol S4:004 doi:10.4172/2155-9899.S4-004
Copyright: © 2012 de Freitas AC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Cervical cancer is the second most common form of cancer among women, and responsible for 274,000 deaths each year, most of which occur in developing countries. Persistent infection with high-risk human papillomavirus (HR-HPV) is an essential factor in the development of cervical cancer and also a contributory factor in other types of cancer. The current prophylactic HPV vaccines provide protection against the -16 and -18 genotypes which are most commonly associated with cervical cancer worldwide. However, the increased costs of these vaccines inhibit their implementation in developing countries, affecting their viability. Moreover, a therapeutic vaccine is needed for women who are already infected by HPV and/or affected by HPV-related cancer. A number of innovative approaches to combat and treat HPV infection are currently being studied and some of these will be consider in this work, together with the development of new vaccines, especially in seriously affected areas located in developing countries. At the same time, there will be a discussion of the issues involved in carrying out effective HPV vaccination programs; these will take account of financial constraints, the lack of adequate infrastructure and the competing priorities, that are found in the surrounding social context of the developing countries.

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