alexa Validation of A Point-of-Care Lactate Device For Screen
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Short Communication

Validation of A Point-of-Care Lactate Device For Screening At-Risk Adults Receiving Combination Antiretroviral Therapy In Botswana

Sikhulile Moyo1*, Hermann Bussmann1,2, Phibeon Mangwendeza1, Priti Dusara1, Tendani Gaolathe1, Madisa Mine1,3, Rosemary Musonda1,2, Erik van Widenfelt1, Vladimir Novitsky1,2, Joseph Makhema1, Richard G. Marlink1,2, Max Essex1,2 and C. William Wester1,2,4

1Botswana–Harvard AIDS Institute Partnership, Gaborone, Botswana

2Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA

3National Health Laboratory, Gaborone

4Vanderbilt University School of Medicine, Vanderbilt Institute for Global Health (VIGH), Nashville, TN, USA

*Corresponding Author:
Mr. Sikhulile Moyo Moyo
Botswana–Harvard AIDS Institute Partnership
P/Bag BO 320 Gaborone, Botswana
Tel: +267 3902671
Fax: +267 3901284
E-mail: [email protected]

Received Date: July 16, 2011; Accepted Date: August 21, 2011; Published Date: September 20, 2011

Citation: Moyo S, Bussmann H, Mangwendeza P, Dusara P, Gaolathe T, et al. (2011) Validation of A Point-of-Care Lactate Device For Screening At-Risk Adults Receiving Combination Antiretroviral Therapy in Botswana. J Antivir Antiretrovir 3: 045-048. doi: 10.4172/jaa.1000034

Copyright: ©2011 Moyo S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: Nucleoside reverse-transcriptase inhibitors (NRTIs) are a major component of combination antiretroviral therapy (cART) worldwide but they have been associated with mitochondrial toxicities, with one of the most significant being lactic acidosis. In southern Africa, being female and overweight (BMI > 25) as well as receiving d4T and/or ddI-based cART are risk factors for the development of this potentially life-threatening complication. It is challenging in many resource-limited settings to obtain reliable serum lactate measurements while screening for the presence of lactic acidosis. Point-of-care devices, however, are now available that provide simple, accurate measurements of serum lactate levels at relatively low cost. The objective of this study was to assess the agreement of the portable (Accutrend™ handheld) lactate analyzer to the conventional laboratory system for obtaining serum lactate. Methods: Eighty two “at-risk” cART-treated adults were evaluated, having their lactate levels tested in parallel using both modalities. Results: The mean (range) lactate level for the portable device was 2.28 (0.9-5.0) compared to 1.96 (0.7- 5.4) using the conventional method. There was a strong correlation (p<0.05) between the portable device and the conventional means with a Pearson correlation coefficient of 0.92 [95% CI: 0.88-0.95]. The mean bias was 0.33 [95% CI: -0.39-1.04], with the portable device having slightly higher values. Conclusion: The use of a portable lactate device provides an accurate and user-friendly means of screening at-risk patients for the presence of lactic acidosis in resource-limited settings with limited laboratory capacity.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords