alexa Validation of EGOS-600 Near Infrared Spectroscopy to Measure Cerebral Oxygen Saturation by Comparing to NIRO-200nx <em>In Vitro</em> and <em>In Vivo</em> | Abstract
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Research Article

Validation of EGOS-600 Near Infrared Spectroscopy to Measure Cerebral Oxygen Saturation by Comparing to NIRO-200nx In Vitro and In Vivo

Ding Han1, Hui Zhang2, Bai-Yu Tian3, Yan Zhu3, Dan Zhang3, Yue Li4, Yi-Chao Teng4, Hong Gu3, Xu Meng3, Yi Luo1, De-Ming Zhu5* and Jia Li2*

1Department of Anesthesia, Capital Institute of Paediatrics, Beijing, PR. China

2Clinical Physiology Research Laboratory, Capital Institute of Paediatrics, Beijing, PR. China

3Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, PR. China

4School of Medicine, Tsinghua University, Beijing, PR. China

5Extracorporeal Circulation Department, Shanghai Children's Medical Center, Shanghai, PR. China

*Corresponding Authors:
Jia Li
Clinical Physiology Research Laboratory
Capital Institute of Pediatrics, 2 Yabao Street
Chaoyang District, Beijing, PR. China
Tel: 010-85628194
Fax: 010-85628194
E-mail: [email protected]
De-Ming Zhu
Extracorporeal Circulation Department
Shanghai Children's Medical Center, Shanghai, PR. China
Tel: +86-21-38626161
E-mail: [email protected]

Received date: April 7, 2016; Accepted date: April 26, 2016; Published date: April 30, 2016

Citation: Han D, Zhang H, Tian B, Zhu Y, Zhang D, et al. (2016) Validation of EGOS-600 Near Infrared Spectroscopy to Measure Cerebral Oxygen Saturation by Comparing to NIRO-200nx In Vitro and In Vivo. J Clin Exp Cardiolog 7:440. doi:10.4172/2155-9880.1000440

Copyright: © 2016 Han D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: Near-infrared spectroscopy (NIRS) has been increasingly used to monitor regional cerebral oxygen saturation (rScO2) during cardiac surgery and intensive care. NIRO-200nx (Hamamatsu Phototonics, Japan) is one of widely used NIRS devices. EGOS-600 is a new device developed by Tsinghua University in China. We validated EGOS-600 by comparing to NIRO-200nx in laboratory and clinical settings.
Materials and methods: Laboratory test : A liquid tissue model was made consisting of 40 ml of human whole blood, 25 ml intralipid-20% and 935 ml buffer solution. Oxygen saturation (SO2) levels ranging 20-100% were made by inflating oxygen or adding sodium hydrosulfite. Eleven pairs of measures were obtained using the two oximeters.
Clinical test: 31 children (aged 0.7-61 months, median 11 months) and 20 adults (aged 18-73 years, median 59 years) were enrolled within one week after cardiac surgery. One probe of each device was sequentially placed at the middle of patient’s forehead to measure rScO2 at 2-3 hour intervals. One hundred pairs of rScO2 were obtained in each group. Bland-Altman method was used for data analysis.
Results: Laboratory test showed a bias of-2% and limits of agreement 20 to-24% with a trend of overestimating SO2 by EGOS-600 when average SO2>50% and underestimating when <50%. This trend disappeared in patients. The bias was-5.9% in children and-4.1% in adults. The limits of agreement were 1.3 to-13.1% in children, and 3.3 to-11.5% in adults.
Conclusions: EGOS-600 introduces a small underestimation of rScO2 when compared to NIRO-200nx, with acceptable limits of agreement. The new device is applicable in clinical settings in both children and adults.


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