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Validation of Updated Partinandrsquo;s Table in Pakistani Patients undergoing Radical Prostatectomy for Prostate Cancer | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Research Article

Validation of Updated Partin’s Table in Pakistani Patients undergoing Radical Prostatectomy for Prostate Cancer

Syed M Nazim1*, Farhat Abbas1, Nuzhat Faruqui1Muhammad Islam2and Zubair Ahmad3

1Departments of Surgery, Aga Khan University, Karachi, Pakistan

2Community Health Sciences, Aga Khan University, Karachi, Pakistan

3Pathology & Microbiology, Aga Khan University, Karachi, Pakistan

*Corresponding Author:
Farhat Abbas, MD
FCPS, FRCSEd, FRCS, FEBU, FACS
The Hussein. Cumber, Professor (Urology)
Aga Khan University, Stadium Road
PO Box 3500, Karachi-74800, Pakistan
Tel: (92) 21 34864402 / 34864409
Fax: (92) 21 34934294
E-mail: [email protected]

Received Date: September 28, 2010; Accepted Date: November 02, 2011; Published Date: November 04, 2011

Citation: Nazim SM, Abbas F, Faruqui N, Islam M, Ahmad Z (2011) Validation of Updated Partin’s Table in Pakistani Patients undergoing Radical Prostatectomy for Prostate Cancer J Cancer Sci Ther S1:010. doi:10.4172/1948-5956.S1-010

Copyright: © 2011 Nazim SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objectives: To establish the usefulness and validity of 2007 Partin’s table in our population with prostate cancer.

Materials and methods: Between January 1998 to June 2009, all patients with clinically localized carcinoma prostate who were treated with intent of radical retro-pubic prostatectomy (RRP) were included. Clinical, operative and pathological data was gathered. All biopsy and final histopathology Gleason scores were re-assigned in a double blind manner. Pre-operative serum PSA, TNM clinical stage and biopsy Gleason scores were plotted on Partin’s table and its predictive value and pathological findings of specimen were compared and analyzed by using Receiver operating characteristic (ROC) analysis.

Results: A total of 109 of 138 patients were included in final analysis. The median age was 65 ± 5.8 years. The pre-operative serum PSA values and clinical stages were higher in our cohort of patients as compared to Partin’s cohort. At pathological assessment of resected specimen, organ confined disease was present in 58 % of patients, seminal vesicles were involved in 22 % and lymph node metastasis was present in 12 % of patients. The accuracy of Partin’s table derived probability was high with area under curve (AUC) of 0.82 for organ confinement, 0.805 for seminal vesicle involvement and 0.714 for lymph node involvement respectively.

Conclusions: The 2007 Partin’s table has a reasonably high predictive value for the final histo-pathological features. This predictive model can be used in Pakistani patients with carcinoma prostate with comparable accuracy.

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