alexa Validation of Updated Partin?s Table in Pakistani Patie
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Validation of Updated Partin?s Table in Pakistani Patients undergoing Radical Prostatectomy for Prostate Cancer

Syed M Nazim1*, Farhat Abbas1, Nuzhat Faruqui1Muhammad Islam2and Zubair Ahmad3

1Departments of Surgery, Aga Khan University, Karachi, Pakistan

2Community Health Sciences, Aga Khan University, Karachi, Pakistan

3Pathology & Microbiology, Aga Khan University, Karachi, Pakistan

*Corresponding Author:
Farhat Abbas, MD
FCPS, FRCSEd, FRCS, FEBU, FACS
The Hussein. Cumber, Professor (Urology)
Aga Khan University, Stadium Road
PO Box 3500, Karachi-74800, Pakistan
Tel: (92) 21 34864402 / 34864409
Fax: (92) 21 34934294
E-mail: [email protected]

Received Date: September 28, 2010; Accepted Date: November 02, 2011; Published Date: November 04, 2011

Citation: Nazim SM, Abbas F, Faruqui N, Islam M, Ahmad Z (2011) Validation of Updated Partin’s Table in Pakistani Patients undergoing Radical Prostatectomy for Prostate Cancer J Cancer Sci Ther S1:010. doi:10.4172/1948-5956.S1-010

Copyright: © 2011 Nazim SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objectives: To establish the usefulness and validity of 2007 Partin’s table in our population with prostate cancer.

Materials and methods: Between January 1998 to June 2009, all patients with clinically localized carcinoma prostate who were treated with intent of radical retro-pubic prostatectomy (RRP) were included. Clinical, operative and pathological data was gathered. All biopsy and final histopathology Gleason scores were re-assigned in a double blind manner. Pre-operative serum PSA, TNM clinical stage and biopsy Gleason scores were plotted on Partin’s table and its predictive value and pathological findings of specimen were compared and analyzed by using Receiver operating characteristic (ROC) analysis.

Results: A total of 109 of 138 patients were included in final analysis. The median age was 65 ± 5.8 years. The pre-operative serum PSA values and clinical stages were higher in our cohort of patients as compared to Partin’s cohort. At pathological assessment of resected specimen, organ confined disease was present in 58 % of patients, seminal vesicles were involved in 22 % and lymph node metastasis was present in 12 % of patients. The accuracy of Partin’s table derived probability was high with area under curve (AUC) of 0.82 for organ confinement, 0.805 for seminal vesicle involvement and 0.714 for lymph node involvement respectively.

Conclusions: The 2007 Partin’s table has a reasonably high predictive value for the final histo-pathological features. This predictive model can be used in Pakistani patients with carcinoma prostate with comparable accuracy.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords