alexa Variants of PGIS and PPARγ in Idiopathic Pulmona
ISSN: 2472-128X

Journal of Clinical & Medical Genomics
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Variants of PGIS and PPARγ in Idiopathic Pulmonary Arterial Hypertension

Shivani Vadapalli1, Chaitra KL1, Satyanarayana ML1, Surekha Rani H1, Sastry BKS2 and Pratibha Nallari1*
1Department of Biology, Delhi University, Delhi
2Department of Biochemistry, Delhi University, Delhi
Corresponding Author : Pratibha Nallari
Department of Biology
Delhi University,India
Tel: 91 888 548 6499
E-mail: [email protected]
Received: September 09, 2015 Accepted: October 06, 2015 Published: October 12, 2015
Citation: Vadapalli S, Chaitra KL, Satyanarayana ML, Surekha Rani H, Sastry BKS, et al. (2015) Variants of PGIS and PPARγ in Idiopathic Pulmonary Arterial Hypertension. J Clin Med Genomics 3:130. doi: 10.4172/2472-128X.1000130
Copyright: © 2015 Vadapalli S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at Pubmed, Scholar Google


Introduction: Idiopathic Pulmonary Arterial Hypertension (IPAH) is a subset of a heterogeneous group of diseases called Pulmonary Arterial Hypertension (PAH), characterized by elevated pulmonary arterial pressure (PAP) and is associated with severe arteriopathy, vascular lesions, and right heart failure. The role of prostacyclin synthase, an enzyme responsible for production of prostacyclin, and peroxisome proliferator-activated receptor gamma, involved in many cellular activities, is studied here. Objectives: The objective of the study is to determine any association of prostacyclin synthase and Peroxisome proliferator-activated receptor gamma with Idiopathic Pulmonary Arterial Hypertension Materials and methods: A total of 77 IPAH patients and 100 controls were genotyped using PCR SSCP and RFLP, and appropriate statistical tests were employed to determine the significance and to interpret the results. Results and conclusion: This study has attempted to correlate promoter/gene polymorphisms of PGIS to its activity, and it can be concluded that the VNTR polymorphism and the polymorphism found in exon 6 may not have an effect on the levels of PGIS. The alanine variant of P12A polymorphism of PPARγ was found to be significantly associated with a reduced risk of IPAH.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version