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ISSN: 2161-1025

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Review Article

Vascular Aging: Implications for Cardiovascular Disease and Therapy

Yohannes T Ghebre1*, Eduard Yakubov2, Wing Tak Wong3, Prasanna Krishnamurthy4, Nazish Sayed5, Andrew G Sikora6and Mark D Bonnen1

1Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas, USA

2phaRNA Comprehensive RNA Technologies, Houston, Texas, USA

3School of Life Sciences, The Chinese University of Hong Kong, Hong Kong

4Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA

5Department of Medicine, Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA

6Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA

*Corresponding Author:
Yohannes T Ghebre
Department of Radiation Oncology
Baylor College of Medicine, Houston
Texas 77030, USA
Tel: +713-798-3619
Fax: +713-798-6923
E-mail: [email protected]

Received date: July 26, 2016; Accepted date: August 11, 2016; Published date: August 30, 2016

Citation: Ghebre YT, Yakubov E, Wong WT, Krishnamurthy P, Sayed N, et al. (2016) Vascular Aging: Implications for Cardiovascular Disease and Therapy. Transl Med (Sunnyvale) 6:183. doi:10.4172/2161-1025.1000183

Copyright: © 2016 Ghebre YT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The incidence and prevalence of cardiovascular disease is highest among the elderly, in part, due to deleterious effects of advancing age on the heart and blood vessels. Aging, a known cardiovascular risk factor, is progressively associated with structural and functional changes to the vasculature including hemodynamic disturbance due to increased oxidative stress, premature cellular senescence and impairments in synthesis and/or secretion of endothelium-derived vasoactive molecules. These molecular and physiological changes lead to vessel wall stiffening and thickening, as well as other vascular complications that culminate to loss of vascular tone regulation and endothelial function. Intriguingly, the vessel wall, a biochemically active structure composed of collagen, connective tissue, smooth muscle and endothelial cells, is adversely affected by processes involved in premature or normal aging. Notably, the inner most layer of the vessel wall, the endothelium, becomes senescent and dysfunctional with advancing age. As a result, its ability to release vasoactive molecules such as acetylcholine (ACh), prostacyclin (PGI2), endothelium-derived hyperpolarizing factor (EDHF), and nitric oxide (NO) is reduced and the cellular response to these molecules is also impaired. By contrast, the vascular endothelium increases its generation and release of reactive oxygen (ROS) and nitrogen (RNS) species, vasoconstrictors such as endothelin (ET) and angiotensin (AT), and endogenous inhibitors of NO synthases (NOSs) to block NO. This skews the balance of the endothelium in favor of the release of highly tissue reactive and harmful molecules that promote DNA damage, telomere erosion, senescence, as well as stiffened and hardened vessel wall that is prone to the development of hypertension, diabetes, atherosclerosis and other cardiovascular risk factors. This Review discusses the impact of advancing age on cardiovascular health, and highlights the cellular and molecular mechanisms that underlie ageassociated vascular changes. In addition, the role of pharmacological interventions in preventing or delaying agerelated cardiovascular disease is discussed.

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