alexa Vascular Tissue Contractility Changes Following Late Ge
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
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Research Article

Vascular Tissue Contractility Changes Following Late Gestational Exposure to Multi-Walled Carbon Nanotubes or their Dispersing Vehicle in Sprague Dawley Rats

Vidanapathirana AK1, Thompson LC1, Odom J1, Holland NA1, Sumner SJ2, Fennell TR2, Brown JM3 and Wingard CJ1*

1Department of Physiology, Brody School of Medicine, East Carolina University, NC 27834, USA

2Discovery Sciences, RTI International, Research Triangle Park, NC, 27709, USA

3Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, CO, 80045, USA

*Corresponding Author:
Christopher J Wingard
Department of Physiology
Brody School of Medicine at East Carolina University
600 Moye Boulevard, Brody 6N98, Greenville, NC, 27834, USA
Tel: +1-252-744-2804
Fax: +1-252-744-3460
E-mail: [email protected]

Received Date: March 25, 2014; Accepted Date: April 15, 2014; Published Date: April 20, 2014

Citation: Vidanapathirana AK, Thompson LC, Odom J, Holland NA, Sumner SJ, et al. (2014) Vascular Tissue Contractility Changes Following Late Gestational Exposure to Multi-Walled Carbon Nanotubes or their Dispersing Vehicle in Sprague Dawley Rats. J Nanomed Nanotechnol 5:201. doi:10.4172/2157-7439.1000201

Copyright: © 2014 Vidanapathirana AK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Multi-walled carbon nanotubes (MWCNTs) are increasingly used in industry and in nanomedicine raising safety concerns, especially during unique life-stages such as pregnancy. We hypothesized that MWCNT exposure during pregnancy will increase vascular tissue contractile responses by increasing Rho kinase signaling. Pregnant (17-19 gestational days) and non-pregnant Sprague Dawley rats were exposed to 100 μg/kg of MWCNTs by intratracheal instillation or intravenous administration. Vasoactive responses of uterine, mesenteric, aortic and umbilical vessels were studied 24 hours post-exposure by wire myography. The contractile responses of the vessel segments were different between the pregnant and non-pregnant rats, following MWCNT exposure. Maximum stress generation in the uterine artery segments from the pregnant rats following pulmonary MWCNT exposure was increased in response to angiotensin II by 4.9 mN/mm2 (+118%), as compared to the naïve response and by 2.6 mN/mm2 (+40.7%) as compared to the vehicle exposed group. Following MWCNT exposure, serotonin induced approximately 4 mN/mm2 increase in stress generation of the mesenteric artery from both pregnant and non-pregnant rats as compared to the vehicle response. A significant contribution of the dispersion medium was identified as inducing changes in the contractile properties following both pulmonary and intravenous exposure to MWCNTs. Wire myographic studies in the presence of a Rho kinase inhibitor and RhoA and Rho kinase mRNA/protein expression of rat aortic endothelial cells were unaltered following exposure to MWCNTs, suggesting absent/minimal contribution of Rho kinase to the enhanced contractile responses following MWCNT exposure. The reactivity of the umbilical vein was not changed; however, mean fetal weight gain was reduced with dispersion media and MWCNT exposure by both routes. These results suggest a susceptibility of the vasculature during gestation to MWCNT and their dispersion media-induced vasoconstriction, predisposing reduced fetal growth during pregnancy.


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