Vasculogenic Mimicry in Merkel Cell Carcinomavan Beurden A1*, van Dijk CM2 and Baeten CIM3
- *Corresponding Author:
- Anne van Beurden
3737 RA Groenekan, The Netherlands
E-mail: [email protected]
Received date: February 20, 2014; Accepted date: April 23, 2014; Published date: April 25, 2014
Citation: van Beurden A, van Dijk CM, Baeten CIM (2014) Vasculogenic Mimicry in Merkel Cell Carcinoma. J Cytol Histol 5:241. doi:10.4172/2157-7099.1000241
Copyright: © 2014 Beurden AV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aims: Angiogenesis, as measured by degree of micro vessel density, has been associated with tumor progression in many tumor types, but does not always correlate with clinical outcome. Aggressive tumor cells were shown to form blood-conducting tubes not lined by endothelial cells, and this phenomenon was termed vasculogenic mimicry. Merkel cell carcinoma is a very aggressive but rare form of skin cancer, of neuroendocrine origin and with increasing incidence. We investigated the presence of vasculogenic mimicry in Merkel cell carcinoma in the Groene Hart Hospital, The Netherlands between 1990-2012.
Methods: Tumor tissues of all patients diagnosed with primary Merkel cell carcinoma in the period 1990-2012 in the Groene Hart Ziekenhuis were assessed on the presence of vasculogenic mimicry.
Results: We found vasculogenic mimicry in 11 (100%) out of the eleven patients primary diagnosed with Merkel cell carcinoma.
Conclusions: Vasculogenic mimicry is present in all Merkel cell carcinoma we found in our database and appears to be comparable to vasculogenic mimicry described in other tumors. Further investigation to vasculogenic mimicry can probably help us in finding a better understanding of the behaviour of Merkel cell carcinoma consequently a better treatment.