Vasorelaxant Effects of Aqueous Extract of Zygophyllum Album and Antihyperglycemic Activities in Streptozotocin-Induced Diabetic MiceEmilio Giugliano1*, Elisa Cagnazzo1, Brunella Giugliano1, Donatella Caserta2, Massimo Moscarini2 and Roberto Marci1
- *Corresponding Author:
- Emilio Giugliano
Department of Morphology, Surgery and Experimental Medicine
Section of Obstetrics and Gynecology, University of Ferrara
CorsoGiovecca 203, Ferrara, Italy 44121
E-mail: [email protected]
Received date: July 24, 2013; Accepted date: August 21, 2013; Published date: August 26, 2013
Citation: Giugliano E, Cagnazzo E, Giugliano B, Caserta D, Moscarini M, et al. (2013) The Prevention of Gestational Diabetes. J Diabetes Metab 4:286. doi: 10.4172/2155-6156.1000286
Copyright: © 2013 Giugliano E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Zygophyllum album has been mentioned in Tunisian system of traditional medicine to be of value in the treatment of diabetes mellitus. The aqueous extract from Zygophyllum album were examined for relaxant effects in isolated mice thoracic aorta, Nitric Oxide (N0) spin-trapping technique combined with Electron Paramagnetic Resonance (EPR) spectroscopy has been employed to measure the ex vivo production of NO in liver, heart, pancreas and aorta. The antihyperglycemic effects of aqueous extract from Zygophyllum album (100 and 300 mg/kg bw) during 15 days on important enzymes of carbohydrate metabolism in livers of non- diabetic and streptozotocin-induced diabetic mice was evaluated. Administration of the aqueous extract plant (100 and 300 mg/kg bw) for 15 days resulted in significant reduction in hepatic Glucokinase (GK), glycogen in STZ diabetic mice. In addition to that, significant increase in hepatic Phosphofructokinase (PFK), Glucose-6 Phosphate Dehydrogenase (G6PDH) observed in STZ diabetic mice.