alexa Vasorelaxant Effects of Aqueous Extract of Zygophyllum Album and Antihyperglycemic Activities in Streptozotocin-Induced Diabetic Mice
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Vasorelaxant Effects of Aqueous Extract of Zygophyllum Album and Antihyperglycemic Activities in Streptozotocin-Induced Diabetic Mice

Emilio Giugliano1*, Elisa Cagnazzo1, Brunella Giugliano1, Donatella Caserta2, Massimo Moscarini2 and Roberto Marci1

1 Department of Morphology, Surgery and Experimental Medicine, Section of Obstetrics and Gynecology, University of Ferrara, Italy

2 Department of Woman’s Health and Territorial Medicine, Faculty of Medicine and Psychology, University of Rome La Sapienza, Italy

*Corresponding Author:
Emilio Giugliano
Department of Morphology, Surgery and Experimental Medicine
Section of Obstetrics and Gynecology, University of Ferrara
CorsoGiovecca 203, Ferrara, Italy 44121
Tel: +390532236297
E-mail: [email protected]

Received date: July 24, 2013; Accepted date: August 21, 2013; Published date: August 26, 2013

Citation: Giugliano E, Cagnazzo E, Giugliano B, Caserta D, Moscarini M, et al. (2013) The Prevention of Gestational Diabetes. J Diabetes Metab 4:286. doi: 10.4172/2155-6156.1000286

Copyright: © 2013 Giugliano E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Zygophyllum album has been mentioned in Tunisian system of traditional medicine to be of value in the treatment of diabetes mellitus. The aqueous extract from Zygophyllum album were examined for relaxant effects in isolated mice thoracic aorta, Nitric Oxide (N0) spin-trapping technique combined with Electron Paramagnetic Resonance (EPR) spectroscopy has been employed to measure the ex vivo production of NO in liver, heart, pancreas and aorta. The antihyperglycemic effects of aqueous extract from Zygophyllum album (100 and 300 mg/kg bw) during 15 days on important enzymes of carbohydrate metabolism in livers of non- diabetic and streptozotocin-induced diabetic mice was evaluated. Administration of the aqueous extract plant (100 and 300 mg/kg bw) for 15 days resulted in significant reduction in hepatic Glucokinase (GK), glycogen in STZ diabetic mice. In addition to that, significant increase in hepatic Phosphofructokinase (PFK), Glucose-6 Phosphate Dehydrogenase (G6PDH) observed in STZ diabetic mice.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version