alexa Verner-Morrison Syndrome Presenting as Acute Persistent Diarrhea
ISSN: 2165-7920

Journal of Clinical Case Reports
Open Access

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Case Report

Verner-Morrison Syndrome Presenting as Acute Persistent Diarrhea

Eliseo De La Cruz-Escobar1, Ignacio García Juárez2, Shaddai Urbina3 and Jonathan Aguirre-Valadez2*
1Resident of Oncology, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, Mexico
2Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, Mexico
3Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, Mexico
*Corresponding Author : Jonathan Aguirre-Valadez
Department of Gastroenterology
Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”
Mexico City, Mexico
Tel: 55 0445527558049
E-mail: [email protected]
Received: December 14, 2015 Accepted: February 25, 2016 Published: February 28, 2016
Citation: Cruz-Escobar EDL, Juárez IG, Urbina S, Aguirre-Valadez J (2016) Verner-Morrison Syndrome Presenting as Acute Persistent Diarrhea. J Clin Case Rep 6:729. doi:10.4172/2165-7920.1000729
Copyright: © 2016 Cruz-Escobar EDL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Vasoactive intestinal peptide (VIP)-producing tumors account for 10% of all neuroendocrine tumors of the pancreas. The Verner-Morrison syndrome is caused by VIP-producing tumors. It is a rare entity with an incidence of 1/10 million individuals per year. About 800 cases have been reported worldwide. Pancreatic VIPomas are usually solitary. Clinical manifestations are long-standing secretory diarrhea associated to biochemical abnormalities such as hypokalemia, hypochloremia and metabolic acidosis, presentation as acute diarrhea is rare. Up to 60% of tumors are malignant and among these, 60-80% have metastasized at diagnosis. Part of the symptomatic treatment is based on somatostatin analogs; definitive treatment depends on the disease’s extent but surgical resection is the treatment of choice of localized tumors.

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