alexa Vigabatrin Retinal Toxicity First Detected with Electroretinographic Changes: A Case Report
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
Open Access

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Case Report

Vigabatrin Retinal Toxicity First Detected with Electroretinographic Changes: A Case Report

Dianne Barrett1, Jin Yang2, Tharikarn Sujirakul2 and Stephen H. Tsang2,3,4*
1College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA
2Edward S. Harkness Eye Institute, Columbia University, New York, NY 10032, USA
3Bernard & Shirlee Brown Glaucoma Laboratory, Departments of Ophthalmology, Pathology & Cell Biology, Columbia University, New York, NY 10032, USA
4New York-Presbyterian Hospital/Columbia University Medical Center, New York, NY 10032, USA
Corresponding Author : Stephen H. Tsang
Edward S. Harkness Eye Institute
New York-Presbyterian/Columbia University Medical Center
160 Fort Washington Ave. Research Annex
Room 513, New York, NY 10032, USA
Tel: +212 3421189
Fax: +212 3054987
E-mail: [email protected], [email protected]
Received May 23, 2014; Accepted October 14, 2014; Published October 17, 2014
Citation: Barrett D, Yang G, Sujirakul T, Tsang SH (2014) Vigabatrin Retinal Toxicity First Detected with Electroretinographic Changes: A Case Report. J Clin Exp Ophthalmol 5:363. doi: 10.4172/2155-9570.1000363
Copyright: © 2014 Barrett D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Vigabatrin is an effective antiepileptic drug (AED) typically used in the treatment of refractory partial seizures and infantile spasms. Its use, however, is limited due to the concern of retinal toxicity and subsequent visual field defects. Herewith in we describe a case of vigabatrin toxicity that illustrates electroretinographic (ERG) changes occur before imaging and visual field deterioration. Decrease in maximal ERG b:a ratio was observed before thinning of the retinal nerve fiber layer (RNFL) on optical coherence tomography (OCT).

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