alexa Viral Disease, Tissue Injury, Repair and Regeneration
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Review Article

Viral Disease, Tissue Injury, Repair and Regeneration

Nicholas Ten1, Deisy Contreras1, Vidhya Kanagavel1 and Vaithilingaraja Arumugaswami1,2,3*

1The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, California, USA

2Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, California, USA

3Department of Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles CA 90095, California, USA

*Corresponding Author:
Vaithilingaraja Arumugaswami
MVSc., PhD, The Board of Governors Regenerative Medicine Institute
Cedars-Sinai Medical Center, Los Angeles, CA 90048, California, USA
Tel: +1 310 248 8584
Fax: +1 310 248 8066
E-mail: [email protected]

Received Date: July 08, 2014; Accepted Date: November 20, 2014; Published Date: November 27, 2014

Citation: Ten N, Contreras D, Kanagavel V, Arumugaswami V (2014) Viral Disease, Tissue Injury, Repair and Regeneration. J Mol Genet Med 8:148. doi: 10.4172/1747-0862.1000148

Copyright: © 2014 Nicholas T et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.




Adult stem cells present in various tissues play key roles in tissue repair and regeneration upon injury. The inflammatory responses associated with tissue damage that are caused by physical, chemical, infectious, nutritional and genetic factors activate stem cells to proliferate and differentiate. The severity and duration of the injury influence the outcome of tissue repair. Viral diseases are major public health problems and over 500 million people worldwide are affected with viral hepatitis. Virus infection of acute or chronic nature could disrupt the tissue homeostasis by altering cell function and architecture. Little is known about the effect of viral diseases on resident stem or progenitor cell population during tissue repair and the regeneration process. This review summarizes the liver-specific inflammatory and healing responses to injury and provides a detailed overview of the cellular and molecular basis of tissue regeneration following viral diseases. Understanding the behavior of resident stem or progenitor cells in response to tissue injury caused by infectious agents such as viruses can allow for the development of small molecule and cell-based therapy for tissue regeneration.


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