alexa Virosomes-Hybrid Drug Delivery Systems
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
Open Access

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Review Article

Virosomes-Hybrid Drug Delivery Systems

Mustafeez Mujtaba Babar1 , Najam-us-Sahar Sadaf Zaidi1 , Alvina Gul Kazi1* and Abdul Rehman2

1Atta urRahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan

2Poultry Research Institute, Ministry of Livestock and Dairy Development Punjab, Shamsabad Rawalpindi, Pakistan

*Corresponding Author:
Alvina Gul Kazi
School of Applied Biosciences
National University of Sciences and Technology
H-12, Islamabad
Tel: +92-51-90856126
Fax: +92-51-90856102
E-mail: [email protected]

Received Date: October 28, 2013; Accepted Date: November 28, 2013; Published Date: December 02, 2013

Citation: Babar MM, Zaidi NSS, Kazi AG, Rehman A (2013) Virosomes-Hybrid Drug Delivery Systems. J Antivir Antiretrovir 5:166-172. doi: 10.4172/jaa.1000083

Copyright: © 2013 Babar MM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The development of safe and effective models for the delivery of any prophylactic or therapeutic agent remains an uphill task for pharmaceutical formulation developers. Drug molecules, nucleic acids, carbohydrates, proteins and a variety of other biological and chemical entities are used for attaining pharmacological benefits. However, the major challenge remains in the delivery of these agents to the specific site of action in a time-efficient manner. Among the many drug delivery systems developed, the nano scale technology of virosomes tends to present an established system of delivering the therapeutic agents to the site of pharmacological action. Virosomes are lipid bilayer, unilamellar structures that present viral protein on their surface. They are safe, biocompatible and biodegradable structures that can achieve ideal pharmacological profile once administered into the body. Tissue targeting, immune activation and potentiation are the chief advantages that make them efficient prophylactic and therapeutic agents. The review presents the biopharmaceutical applications of virosomes and the immunological and pharmaceutical considerations that make them efficient agents for targeting spatiotemporal parameters in the body.

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