alexa Visceral Leishmaniasis in Renal Transplant Recipients: Study of 30 Cases | OMICS International | Abstract
ISSN: 2161-0959

Journal of Nephrology & Therapeutics
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Research Article

Visceral Leishmaniasis in Renal Transplant Recipients: Study of 30 Cases

Alves Da Silva A1,2*, Barros da Silva DM2, Chaves RV2, Cintra Sesso R3, Pacheco-Silva A3,4, Oliveira CMC5, Fernandes PFCBC5, Oliveira RA5, Esmeraldo RM6, Andrade JX7 and Costa CHN8

1Department of General Practice, Division of Nephrology, Federal University of Piaui, Brazil

2Renal Transplant Unit, Hospital Alianca Casamater, Piauí, Brazil

3Discipline of Nephrology, Federal University of São Paulo, São Paulo, Brazil

4RenalTransplant Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil

5Hospital Universitário Walter Cantídio, Renal Transplant Unit, University Federal do Ceará, Ceará, Brazil

6Renal Transplant Unit of the Hospital Geral de Fortaleza, Ceará, Brazil

7Department of Accounting and Administration. Federal University of Piauí, Piauí, Brazil

8Hospital de Doencas Infecciosas Dr. Natan Portela, Federal University of Piauí, Piauí, Brazil

*Corresponding Author:
Alvelar Da Silva A
Professor, Department of General Practice
Division of Nephrology, Federal University of Piaui, Brazil
Tel: +558699819904
E-mail: [email protected]

Received Date: July 09, 2014; Accepted Date: September 19, 2014; Published Date: September 28, 2014

Citation: Alves Da Silva A, Cintra Sesso R, Pacheco-Silva A, Oliveira CMC, Oliveira RA et al., (2014) Visceral Leishmaniasis in Renal Transplant Recipients: Study of 30 Cases. J Nephrol Ther 4:182. doi:10.4172/2161-0959.1000182

Copyright: © 2014 Alves Da Silva A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Introduction: Visceral leishmaniasis is a disease caused by the protozoan Leishmania sp. and is transmitted by Lutzomyia longipalpis (sand fly). In renal transplant recipients, Visceral Leishmaniasis causes severe damage to the liver, spleen, and hematopoietic system as well as poor outcomes for patients and transplanted kidneys. This study describes the largest series of cases of this disease in renal transplant recipients, providing important information about the diagnostic routines and therapeutic strategies in this patient population. Methods: A retrospective, descriptive study was performed to analyze the distribution and evaluate the extent of the epidemiologic, clinical, diagnostic, and therapeutic aspects of 30 renal transplant recipients from endemic regions who presented with Visceral Leishmaniasis in the post-transplantation period. Results: In this study, Visceral Leishmaniasis was more frequent in men (80%); the mean age of presentation was 40±10.5 years. The majority (66.7%) of patients worked in urban areas. Most of the patients (90%) cohabitated with domestic animals and were from low-income households. In 73.3% of cases, diagnosis was made by direct isolation of Leishmania forms. The drug chosen for treatment was liposomal amphotericin, resulting in a high degree of disease remission (80%). Conclusion: This study describes the largest series of Visceral Leishmaniasis in renal transplant recipients and expands clinical-epidemiological knowledge for transplantation teams to perform adequate disease management for this specific patient population

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