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Viscosupplementation with Hyaluronic Acid or Polynucleotides: Results and Hypothesis for Condro-synchronization | OMICS International | Abstract
ISSN: 2167-0870

Journal of Clinical Trials
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Research Article

Viscosupplementation with Hyaluronic Acid or Polynucleotides: Results and Hypothesis for Condro-synchronization

Saggini R1*, Di Stefano A2, Capogrosso F2, Carniel R3, Haidar Hassan K4 and Bellomo RG5
1Neuroscience and Imaging Department, “G. D’Annunzio” University Chieti, Italy
2School of Specialties in PRM, “G. D’Annunzio” University Chieti, Italy
3Academic School of Specialties in PRM, “G. D’Annunzio” University Chieti, Italy
4CUMS, “G. D’Annunzio” University Chieti, Italy and Libanese University of Beirut
5Medicine and Science of Ageing Department, “G. D’Annunzio” University Chieti, Italy
Corresponding Author : Raoul Saggini
Department of Neuroscience and Imaging
G D’Annunzio University, Chieti, Italy
Tel: 0039 08713553006
E-mail: [email protected]
Received September 22, 2014; Accepted November 24, 2014; Published November 26, 2014
Citation: Saggini R, Di Stefano A, Capogrosso F, Carniel R, Haidar Hassan K, et al. (2014) Viscosupplementation with Hyaluronic Acid or Polynucleotides: Results and Hypothesis for Condro-synchronization. J Clin Trials 4:198. doi:10.4172/2167-0870.1000198
Copyright: © 2014 Saggini R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


In literature the treatment of rotator cuff syndrome is basically conservative using NSAIDs, cortisone infiltrations and cryotherapy to relieve pain, electroanalgesia, kinesiotherapy to restore the impaired mobility of the joint and strengthen the muscles, physical therapies using energy such as ultrasound, laser, hyperthermia and shock waves. In the case of lack of response to conservative treatment, arthroscopic surgery can be proposed. International literature is unanimous in considering the viscosupplementation as an effective treatment for reducing pain associated with the rotator cuff syndrome and improve joint function. The intra-articular treatment should ideally not only ensure the
mechanical protection of the articular surface, but also rebalance homeostasis of chondrocytes through the restoration of the microenvironment and nutritional supplements of the joint. The aim of this study was to evaluate the efficacy of viscosupplementation with hyaluronic acid and polynucleotides in the treatment of patients with rotator cuff syndrome for incomplete lesion of the supraspinatus. 80 subjects (43 M - 37 F) aged between 40 and 65 years (average age 54) were evaluated and treated. All they suffered from rotator cuff syndrome with incomplete injury of the tendon of the supraspinatus ascertained clinically and by ultrasound examination and MRI. The subjects were randomly divided into 2
groups (A and B). Group A made 4 sessions of infiltrative treatment with hyaluronic acid, once per week. Group B made 4 sessions of infiltrative treatment with infiltrative polynucleotides, 1 time per week. All subjects performed, during the whole period of treatment, upper limb proprioception and joint ROM functional recovery with Multi Joint System (MJS) at a frequency of 3 weekly sessions each one of 45 minutes. The results are comparable in the two groups in terms of improvement in both short and medium term. In view of these evidences we could hypothesize that the association of supplementation of the 2 elements, given together or temporally delayed could be further significant for an additional
maintenance of results in the long term.