alexa Visual Defect in Oculocutaneous Albinism is Not Associa
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
Open Access

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Case Report

Visual Defect in Oculocutaneous Albinism is Not Associated with Gross Structural Anomaly

Ajose FO1*, Awosanya GOG1, Adekoya BJ1, Jinadu FO2, Cole OM2, Elebute OH2, Ajayi OI2, Awoyemi ZA2 and Akinola RA1

1Lagos State University College of Medicine, Nigeria

2Lagos State University Teaching Hospital, Nigeria

*Corresponding Author:
Dr. Frances O Ajose FRCP (Lond)
Consultant Physician Dermatologist, Lagos State University Teaching Hospital
PO Box 1723 Surulere,LAGOS, Nigeria
Tel: +2348038559066
E-mail: [email protected]

Received date: June 18, 2014; Accepted date: July 15, 2014; Published date: July 22, 2014

Citation: Ajose FO, Awosanya GOG, Adekoya BJ, Jinadu FO, Cole OM, et al. (2014) Visual Defect in Oculocutaneous Albinism is not Associated with Gross Structural Anormaly. J Clin Exp Dermatol Res 5:228. doi:10.4172/2155-9554.1000228

Copyright: © 2014 Ajose FO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: Albinism is a heterogeneous group of inherited non progressive disorders of melanin metabolism. The two main types are Ocular albinism (OA) in which pigment is absent only in the eyes and Oculocutaneous albinism (OCA) in which the eyes, skin and hair lack pigment. The tropical environment, without the protective effect of melanin, predisposes the African OCA to skin cancers. In the eyes fovea maturity is impaired leading to poor vision. All forms of albinism, regardless of the genotype or phenotype, have the same distinctive visual impairment that confers visual acuity ranging from 20/40(6/12) to 20/200(6/60) that significantly limits their education, occupation and recreation. This study set out to use ultrasonography to detect correctable ocular structural anomaly in visually impaired African OCA who also have severe sun-damaged skin.

Materials and methods: In a prospective study, the eyes of 57 consenting Nigerian OCA referred from Dermatology to Radiology for ocular scan were investigated with B-mode ultra-sonogram. The results were compared with matched controls and analyzed by simple descriptive statistics. Results: The age range of the study population was 15 to 62 years (mean 24.6 years) and male: female ratio was 1:2. Of the OCA, 98% and of the controls, 91.2% had normal ocular scans. Vitreous echoes were found in 7.0% of all participants and one (1.8%) of the control participants had cataract. No cataract or other gross structural anomaly was detected in any of the orbital structures of the OCA.

Conclusion: Ultrasound scan reveals no ocular structural abnormalities peculiar to OCA. Even though not statistically significant, there is an intriguing absence of cataract in OCA that is worthy of further investigation

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