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Visual Functions in Locally Advanced Nasopharyngeal Carcinoma Patients after External Beam Radiation | OMICS International | Abstract
ISSN: 2155-9619

Journal of Nuclear Medicine & Radiation Therapy
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Research Article

Visual Functions in Locally Advanced Nasopharyngeal Carcinoma Patients after External Beam Radiation

Imjai Chitapanarux1*, Janejit Choovuthayakorn2, Yupa Sumitsawan3 and Vicharn Lorvidhaya1

1Division of Therapeutic Radiology and Oncology, Faculty of Medicine, Chiang Mai University, Thailand

2Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Thailand

3Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Thailand

*Corresponding Author:
Imjai Chitapanarux, M.D
Division of Therapeutic Radiology and Oncology
Faculty of Medicine, 110 Intawarorose Road
Chiang Mai, 50200, Thailand
Tel: +66-53-945456
Fax: +66-53-945491
E-mail: [email protected]

Received date: February 28, 2012; Accepted date: April 02-2012; Published date: April 05-2012

Citation: Chitapanarux I, Choovuthayakorn J, Sumitsawan Y, Lorvidhaya V (2012) Visual Functions in Locally Advanced Nasopharyngeal Carcinoma Patients after External Beam Radiation. J Nucl Med Radiat Ther 3:126. doi:10.4172/2155-9619.1000126

Copyright: © 2012 Chitapanarux I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Purpose: To evaluate the effects of radiation to the anterior visual pathway in locally advanced nasopharyngeal carcinoma (NPC) patients after low energy photon external beam radiation. Design: A cross-sectional, observational case series.

Methods: Fifty- one patients treated with the same radiotherapy were assessed in visual acuity (VA), color vision, visual field (VF), and contrast sensitivity. The patients with post radiation interval of ≤ 3 years were defined as group 1, of > 3 years as group 2, and healthy volunteers as control group 3. The visual functions were analyzed between the three groups.

Results: One patient in group 1 developed radiation-induced optic neuropathy (RION) with decreased VA, color vision defect, decreased contrast sensitivity, and VF defect. No RION was detected in group 2. There was no statistical significance in color vision defect (P = 0.303) or mean contrast sensitivity (P = 0.235) between the three groups. There was statistical significance in mean contrast sensitivity value (P = 0.044) between the irradiated and non-irradiated group.

Conclusions: This study reported the acceptable incidence of RION in 1.96% of locally advanced NPC patients after external beam radiotherapy. Significant decrease in contrast sensitivity was the subclinical anterior visual pathway abnormality, observed among the irradiated group. Monitoring subjective and objective visual changes is helpful for irradiated patients in detecting and assessing treatment for minimizing long term devastating results on the visual conditions.


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